Abstract
The activation of some subsets of T cells requires the recognition of antigen in association with self Ia determinants1,2. It is not clear, however, whether this is also necessary for the induction of unresponsiveness and the active suppression of haptenspecific T cells. We have studied the regulation of the delayed-type hypersensitivity (DTH) response in mice. Subcutaneous (s.c.) injection of haptenated syngeneic cells primarily activates T helper cells, while intravenous (i.v.) injection results in unresponsiveness and the activation of T suppressor cells3. Presentation of antigen by an I–A-positive antigen-presenting cell (APC) seems to be critical for T helper cell activation4. We now show that the activation of first-order T suppressor cells requires the presentation of hapten on an I–J-positive APC. However, i.v. injection of I–J-depleted haptenated cells also results in haptenspecific unresponsiveness. This non-transferable T-cell tolerance requires the presence of an I–A-positive APC and is genetically restricted. These results suggest that distinct modes of antigen presentation and administration are required for immunity, suppression and non-transferable tolerance.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shevach, E. M. & Rosenthal, A. S. J. exp. Med. 138, 1213–1229 (1973).
Schwartz, R. H., David, C. S., Dorf, M. E., Benacerraf, B. & Paul, W. Proc. natn. Acad. Sci. U.S.A. 75, 2387–2391 (1978).
Chase, M. W. Proc. Soc. exp. Biol. Med. 61, 257–259 (1946).
Sprent, J., Korngold, R. & Molnar-Kimbar, K. Springer Semin. Immunopath. 3, 213–245 (1980).
Lowy, A., Tominaga, A., Drebin, J., Benacerraf, B. & Greene, M. I. J. exp. Med. 157, 353–358 (1983).
Gershon, R. K. Comtemp. Topics Immunobiol. 3, 1–40 (1974).
Zembala, M., Asherson, G. & Colizzi, V. Nature 297, 411–413 (1982).
Minami, M., Nonji, N. & Dorf, M. E. J. exp. Med. 156, 1502–1515 (1982).
Green, E. F. & Colley, D. G. Proc. natn. Acad. Sci. U.S.A. 78, 1152–1156 (1981).
Nossal, G. & Schrader, J. W. Transplantn Rev. 23, 138–158 (1975).
Claman, H. Ann. N. Y. Acad. Sci. 393, 291–299 (1982).
Chiller, J. M., Habicht, G. S. & Weigle, W. O. Science 171, 813–815 (1971).
Matzinger, P. & Watefield, J. D. Nature 285, 492–494 (1980).
Battisto, J. & Bloom, B. Nature 212, 156–157 (1966).
Claman, H. N., Miller, S. D., Sy, M.-S. & Moorehead, J. W. Immun. Rev. 50, 105–132 (1980).
Bach, B.A., Sherman, L., Benacerraf, B. & Greene, M.I. J. Immun. 121, 1460–1468 (1978).
Waldor, M. K., Sriram, S., McDevitt, H. O. & Steinman, L. Proc. natn. Acad. Sci. U.S.A. 80, 2713–2717 (1983).
Berzofsky, J. A. & Richman, L. K. J. Immun. 126, 1898–1904 (1981).
Perry, L. L. & Greene, M. I. J. exp. Med. 156, 480–491 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lowy, A., Drebin, J., Monroe, J. et al. Genetically restricted antigen presentation for immunological tolerance and suppression. Nature 308, 373–375 (1984). https://doi.org/10.1038/308373a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/308373a0
This article is cited by
-
Peripheral nervous system lesions in experimental allergic encephalomyelitis
Acta Neuropathologica (1986)
-
The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis
Acta Neuropathologica (1986)
-
Accessory cell presentation of hapten-modified self
Survey of Immunologic Research (1985)
-
Immunology: Induction of tolerance to self in T lymphocytes
Nature (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
