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Population dynamics of human helminth infections: control by chemotherapy

Nature volume 297, pages 557–563 (1982)Cite this article

Abstract

An analysis is presented of the population dynamics of the major helminth parasites of man with the aim of understanding observed patterns in the age-specific prevalence and intensity of infection. Mathematical models are used to investigate the possibility of controlling helminth diseases by mass chemotherapy, and to explore the advantages of selective treatment of the most heavily infected individuals in a community.

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References

  1. Stoll, N. R. J. Parasit. 33, 1–18 (1947).

    Article  CAS  Google Scholar 

  2. Iarotski, L. S. & Davis, A. Bull. Wld Hlth Org. 58, 115–127 (1981).

    Google Scholar 

  3. Walsh, J. A. & Warren, K. S. New Engl. Med. J. 301, 967–974 (1979).

    Article  CAS  Google Scholar 

  4. Peters, W. in The Relevance of Parasitology to Human Welfare Today (eds Taylor, A. E. & Muller, R.) (Blackwell Scientific, Oxford, 1978).

    Google Scholar 

  5. Warren, K. S. A. Rev. pub. Hlth 2, 101–115 (1981).

    Article  CAS  Google Scholar 

  6. Anderson, R. M. in Population Dynamics (eds Anderson, R. M., Turner, B. D. & Taylor, L. R.) 245–282 (Blackwell Scientific, Oxford, 1979).

    Google Scholar 

  7. Anderson, R. M. Lect. Notes Biomath. 39, 278–322 (1980).

    Article  Google Scholar 

  8. Muller, R. Worm and Disease: A Manual of Medical Helminthology (Heinemann, London, 1975).

    Google Scholar 

  9. Warren, K. S. & Mahmoud, A. A. F. (eds) Geographic Medicine for the Practitioner (University of Chicago Press, 1978).

  10. Schad, G. A. & Rozeboom, L. E. A. Rev. Ecol. Syst. 7, 393–420 (1976).

    Article  Google Scholar 

  11. Smith, M. A., Clegg, J. A., Snary, D. & Trejdosiewicz, A. J. Parasitology 84, 83–92 (1982).

    Article  CAS  Google Scholar 

  12. Van den Bossche, H. Nature 274, 626–630 (1978).

    Article  ADS  Google Scholar 

  13. W. H. O. Tech. Rep. ser. No. 615 (1977).

  14. Anderson, R. M. & May, R. M. Nature 280, 361–367 (1979).

    Article  ADS  CAS  Google Scholar 

  15. May, R. M. & Anderson, R. M. Nature 280, 455–461 (1979).

    Article  ADS  CAS  Google Scholar 

  16. Croll, N. A., Anderson, R. M., Gyorkos, T. W. & Ghadirian, E. Trans. R. Soc. trop. Med. Hyg. 76, 187–197 (1982).

    Article  CAS  Google Scholar 

  17. May, R. M. Math. Biosci. 35, 301–343 (1977).

    Article  Google Scholar 

  18. Nawalinski, T., Schad, G. A. & Choudhury, A. B. Am. J. trop. Med. Hyg. 27, 1152–1161, 1162–1173 (1978).

    Article  CAS  Google Scholar 

  19. Wakelin, D. J. Nature 273, 617–620 (1978).

    Article  ADS  CAS  Google Scholar 

  20. Mitchell, G. F. Adv. Immun. 28, 451–511 (1979).

    Article  CAS  Google Scholar 

  21. Anderson, R. M. & May, R. M. J. Anim. Ecol. 47, 219–248 (1978).

    Article  Google Scholar 

  22. May, R. M. & Anderson, R. M. J. Anim. Ecol. 47, 249–267 (1978).

    Article  Google Scholar 

  23. Anderson, R. M. J. theor. Biol. 82, 283–311 (1980).

    Article  CAS  Google Scholar 

  24. Crofton, H. D. Parasitology 62, 179–193 (1971).

    Article  Google Scholar 

  25. Macdonald, G. Trans. R. Soc. trop. Med. Hyg. 9, 489–506 (1965).

    Article  Google Scholar 

  26. Bradley, D. J. & May, R. M. Trans. R. Soc. trop. Med. Hyg. 72, 262–273 (1978).

    Article  CAS  Google Scholar 

  27. Fisher, R. A. The Genetical Theory of Natural Selection (Clarendon, Oxford, 1930).

    Book  Google Scholar 

  28. Dietz, K. in Population Dynamics of Infectious Diseases: Theory and Applications (ed. Anderson, R. M.) (Chapman & Hall, London, in the press).

  29. Dietz, K. SIAM-SIMS Conf. Ser. 21, 104–121 (1975).

    Google Scholar 

  30. Anderson, R. M. & May, R. M. Science 215, 1053–1060 (1982).

    Article  ADS  MathSciNet  CAS  Google Scholar 

  31. Anderson, R. M. (ed.) Population Dynamics of Infectious Diseases: Theory and Applications (Chapman & Hall, London in the Press).

  32. Anderson, R. M. in Modern Parasitology (ed. Cox, F. E. G. Blackwell Scientific, Oxford, in the press).

  33. Dietz, K. in Population Biology of Infectious Diseases (eds Anderson, R. M.) (Springer, Berlin, in the press).

  34. Bradley, D. J. & McCullough, F. S. Trans. R. Soc. Trop. Med. Hyg. 67, 491–500 (1973).

    Article  CAS  Google Scholar 

  35. Muench, H. Catalytic Models in Epidemiology (Harvard University Press, 1959).

    Book  Google Scholar 

  36. Warren, K. S. J. infect. Dis. 127, 595–609 (1973).

    Article  CAS  Google Scholar 

  37. Smithers, S. R. (ed.). New Developments with Human and Veterinary Vaccines 287–299 (Liss, New York, 1980).

  38. Wagner, W. H. Interdisc. Sci. Rev. 5, 186–203 (1980).

    Article  CAS  Google Scholar 

  39. Chavania, A. P., Swalzelder, J. C., Villarejos, V. M. & Zeledon, R. Am. J. trop. Med. Hyg. 22, 592–595 (1973).

    Article  Google Scholar 

  40. Willett, W. C., Kilama, W. L. & Kihamia, C. M. Am. J. Pub. Hlth 69, 987–991 (1979).

    Article  CAS  Google Scholar 

  41. Janckes, M. F., Cornet, P. & Thunpont, D. Trop. geogr. Med. 31, 111–122 (1979).

    Google Scholar 

  42. Santos, A. et al. Bull. Wld Hlth Org. 57, 793–799 (1979).

    CAS  Google Scholar 

  43. Davis, A. & Wiegner, D. H. G. Bull. Wld Hlth Org. 57, 767–771 (1979).

    CAS  Google Scholar 

  44. Ishizaki, T., Kamo, E. & Boehme, K. Bull. Wld Hlth Org. 57, 787–791 (1979).

    CAS  Google Scholar 

  45. Davis, A., Biles, J. E. & Ulrich, A. M. Bull. Wld Hlth Org. 57, 773–779 (1979).

    CAS  Google Scholar 

  46. Warren, K. S. in Principles and Practice of Infectious Diseases (eds Mandell, G. L., Douglas, R. G. & Bennett, J. E.) (Wiley, New York, 1979).

    Google Scholar 

  47. Arfaa, F. & Ghadirian, E. Am. J. trop. Med. Hyg. 26, 866–871 (1977).

    Article  CAS  Google Scholar 

  48. Smillie, W. G. S. med. J., Nashville 17, 414–499 (1924).

    Google Scholar 

  49. Rougement, A., Boisson, M. E., Borges de Silva, G. & Zander, N. Bull. Wld Hlth Org. 54, 403–410 (1976).

    Google Scholar 

  50. Warren, K. S. & Mahmoud, A. A. F. Trans. Ass. Am. Physns 89, 195–204 (1976).

    CAS  Google Scholar 

  51. Warren, K. S., Siongok, A., Houser, T. K., Ouma, J. H. & Peters, P. A. J. infect. Dis. 138, 849–855; 138, 856–858 (1978).

    Article  CAS  Google Scholar 

  52. Araujo, N., Katz, N., Pinto Dias, E. & Pereira de Souza, C. Am. J. trop. Med. 29, 890–894 (1980).

    Article  CAS  Google Scholar 

  53. Lloyd, S. Parasitology 83, 225–242 (1981).

    Article  CAS  Google Scholar 

  54. Croll, N. A. & Ghadirian, E. Trop. geogr. Med. 33, 241–284. (1981).

    CAS  PubMed  Google Scholar 

  55. Ansari, N. (ed.) Epidemiology and Control of Schistosomiasis (Karger, Basel, 1973).

  56. Anderson, R. M. & May, R. M. Parasitology 79, 63–94 (1979).

    Article  CAS  Google Scholar 

  57. Anderson, R. M. in Vectors of Disease Agents, Interactions with Plants, Animals and Man (eds McKelvey, J. J., Elridge, B. F. & Maramorosch, K.) 13–43 (Praager, New York, 1981).

    Google Scholar 

  58. Krafsur, E. S. & Garrett-Jones, C. Trans. R. Soc. trop. Med. Hyg. 71, 155–160 (1977).

    Article  CAS  Google Scholar 

  59. Cheever, A. W. Am. J. trop. Med. Hyg. 17, 38–64 (1968).

    Article  CAS  Google Scholar 

  60. Hesieh, H. C. Jap. J. Parasit. 19, 508–522 (1970).

    Google Scholar 

  61. Pesigan, T. P. et al. Bull. Wld Hlth Org. 18, 345–455 (1958).

    CAS  Google Scholar 

  62. Bhallacharya, N. C. & Gubler, D. J. Indian J. med. Res. 61, 8–11 (1973).

    Google Scholar 

  63. Hill, R. B. Am. J. Hyg. 6, 19–41 (1926).

    Google Scholar 

  64. Stoll, N. R. Am. J. Hyg. 3, 103–117 (1923).

    Google Scholar 

  65. Cheever, A. W., Kaner, I. A., Elwi, A. M., Moismann, J. E. & Danner, R. Am. J. trop. Med. Hyg. 26, 702–716 (1977).

    Article  CAS  Google Scholar 

  66. Miller, M. J., Krupp, I. M., Little, M. D. & Santos, C. J. Am. med. Ass. 230, 1412–1414 (1974).

    Article  CAS  Google Scholar 

  67. Wolfe, M. S. & Wershing, J. M. J. Am. med. Ass. 230, 1408–1411 (1974).

    Article  CAS  Google Scholar 

  68. Cameron, T. W. M. Parasites and Parasitism (Methuen, London, 1956).

    Google Scholar 

  69. Mahmoud, A. A. F. & Warren, K. S. Clin. Res. 28, 474 (1980).

    Google Scholar 

  70. Dietz, K. Lect. Notes Biomath. 11, 1–15 (1976).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pure and Applied Biology, Imperial College, London University, London, SW7 2BB, UK

    Roy M. Anderson

  2. Department of Biology, Princeton University, Princeton, New Jersey, 08544, USA

    Robert M. May

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  1. Roy M. Anderson
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  2. Robert M. May
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Anderson, R., May, R. Population dynamics of human helminth infections: control by chemotherapy. Nature 297, 557–563 (1982). https://doi.org/10.1038/297557a0

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