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Human body clocks and the timing of sleep

Nature volume 297, pages 23–27 (1982)Cite this article

Abstract

The alternation of sleep and wakefulness in humans exhibits surprising regularities during long-term isolation from the usual time-of-day cues. The inferred domination of our consciousness and physiological states by internal clocks may soon have practical implications for medicine and psychiatry.

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References

  1. Drucker-Colin, R. The Functions of Sleep (eds Shkurovitch, M. & Sterman, M. B.) (Academic, New York, 1979).

    Google Scholar 

  2. Jones, H. S. & Oswald, I. Electroencephalography clin. Neurophysiol. 24, 378–380 (1968).

    CAS  Google Scholar 

  3. Meddis, R., Pearson, A. J. D. & Langford, G. Electroencephalography clin. Neurophysiol. 35, 213–214 (1973).

    CAS  Google Scholar 

  4. Meddis, R. The Sleep Instinct (Routledge & Kegan Paul, London, 1977).

    Google Scholar 

  5. Aschoff, J. & Wever, R. Naturwissenschaften 49, 337–342 (1962).

    ADS  Google Scholar 

  6. Aschoff, J. Science 148, 1427–1432 (1965).

    ADS  CAS  PubMed  Google Scholar 

  7. Siffre, M. Beyond Time (Chatto & Windus, London, 1965).

    Google Scholar 

  8. Mills, J. N. J. Physiol., Land. 174, 217–231 (1964).

    CAS  Google Scholar 

  9. Findley, J. D., Mialer, B. M. & Brady, J. V. in Space Research Laboratory techn. Rep. Ser. (1963) (reproduced in ref. 12).

  10. Schaefer, K. E., Clegg, B. R., Carey, C. R., Dougherty, J. H. & Weybrew, B. B. Aerospace Med. 38, 1002–1018 (1967).

    CAS  PubMed  Google Scholar 

  11. Wever, R. The Circadian System of Man (Springer, Heidelberg, 1979).

    Google Scholar 

  12. Aschoff, J. Life Sci. Space Res. 5, 159–173 (North-Holland, Amsterdam, (1967).

    CAS  PubMed  Google Scholar 

  13. Aschoff, J., Fatranska, M. & Giedke, H. Science 171, 213–215 (1971).

    ADS  CAS  PubMed  Google Scholar 

  14. Weitzman, E. D., Czeisler, C. A. & Moore-Ede, M. C. in Biological Rhythms and Their Central Mechanism (eds Suda, M., Haishi, O. & Nakagawa, H.) (Elsevier, Amsterdam, 1979).

    Google Scholar 

  15. Wever, R. Int. J. Chronobiol. 3, 19–55 (1975).

    CAS  PubMed  Google Scholar 

  16. Weitzman, E. D., Czeisler, C. A., Zimmerman, J. C. & Ronda, J. M. in Circadian and Ultradian Variations of Pituitary Hormones in Man (Martinus Nijhoff, Belgium, in the press).

  17. Weitzman, E. D., Czeisler, C. A., Zimmerman, J. C. & Moore-Ede, M. C. in Neurosecretion and Brain Peptides (eds Martin, J. B., Reichlin, S. & Bick, K.) 475–496 (Raven, New York, 1981).

    Google Scholar 

  18. Kronauer, R. E., Czeisler, C. A., Pilato, S., Moore-Ede, M. C. & Weitzman, E. D. Am. J. Physiol. 242, R3–R17 (1982).

    CAS  Google Scholar 

  19. Kronauer, R. E., Czeisler, C. A., Pilato, S. F., Moore-Ede, M. C. Weitzman, E. D. in Proceedings Intra-science Symposium on New Perspectives in Sleep Research (Santa Monica Symposium, in the press).

  20. Kronauer, R. E. in Mathematical Modeling of Circadian Systems (eds Moore-Ede, M. C. & Czeisler, C. A.) (Raven, New York, 1982).

    Google Scholar 

  21. Jouvet, M., Mouret, J., Chouvet, G. & Siffre, M. in The Neurosciences: 3rd Study Program (eds Schmitt, F. & Worden, F.) 491–497 (MIT Press, Cambridge, Massachusetts, 1974).

    Google Scholar 

  22. Chouvet, G., Mouret, J., Coindet, J., Siffre, M. & Jouvet, M. Electroeoncephalography clin. Neurophysiol. 37, 367–380 (1974).

    CAS  Google Scholar 

  23. Czeisler, C. A. thesis, Stanford Univ. (1978).

  24. Zulley, J. Bericht über den 30, 398–399 (1976).

    Google Scholar 

  25. Zulley, J. & Schulz, H. in 4th Eur. Cong. Sleep Research, Tirgu-Mures, 341–344 (Karger, Basel, 1980).

  26. Zulley, J., Wever, R. & Aschoff, J. Pflugers Arch. ges. Physiol. 391, 314–318 (1981).

    CAS  Google Scholar 

  27. Zulley, J. Sleep 2, 344–346 (1980).

    Google Scholar 

  28. Zulley, J. & Wever, R. in Vertebrate Circadian Systems: Structure and Physiology (eds Aschoff, J., Daan, S. & Groos, G.) (Springer, Berlin, in the press).

  29. Winfree, A. T. in Mathematical Modeling of Circadian Systems (eds Moore-Ede, M. C. & Czeisler, C. A.) (Raven, New York, in the press).

  30. Daan, S. & Beersma, D. in Mathematical Modeling of Circadian Systems (eds Moore-Ede, M. C. & Czeisler, C. A.) (Raven, New York, in the press).

  31. Wever, R. in Mathematical Modeling of Circadian Systems (eds Moore-Ede, M. C. & Czeisler, C. A.) (Raven, New York, in the press).

  32. Borbely, A. in Curr. Topics Neuroendocr. 1 (1981).

  33. Eastman, C. in Mathematical Modeling of Circadian Systems (eds Moore-Ede, M. C. & Czeisler, C. A.) (Raven, New York, 1982).

    Google Scholar 

  34. Eastman, C. in Vertebrate Circadian Systems: Structure and Function (eds Groos, G. A. & Wehr, T. A.) (Springer, Berlin, 1982).

    Google Scholar 

  35. Buck, L. Aviat. Space envir. Med. 51, 805–808 (1980).

    CAS  Google Scholar 

  36. Wever, R. A. Rhythmical Aspects of Behavior (in the press).

  37. Czeisler, C. A., Richardson, G. S., Zimmerman, J. C., Moore-Ede, M. C. & Weitzman, E. D. Photochem. Photobiol. 34, 239–247 (1981).

    CAS  PubMed  Google Scholar 

  38. Orth, D. N. & Island, D. P. J. clin. Endocr. Metab. 29, 479–486 (1969).

    CAS  PubMed  Google Scholar 

  39. Simenhoff, M. L. J. appl. Physiol. 37, 374–376 (1974).

    CAS  PubMed  Google Scholar 

  40. Webb, W. B. & Agnew, H. W. Aerospace Med. 45, 701–704 (1974).

    CAS  PubMed  Google Scholar 

  41. Aschoff, J. Ergonomics 21, 739–754 (1978).

    CAS  PubMed  Google Scholar 

  42. Nafarrate, A. B. & Miles, L. E. M. Proc. XIV int. Conf. int. Soc. Chronobiol. (II Ponte, Milan, 1982).

  43. Minors, D. S. & Waterhouse, J. M. Int. J. Chronobiol. 7, 165–188 (1981).

    CAS  PubMed  Google Scholar 

  44. Sulzman, F. M., Fuller, C. A. & Moore-Ede, M. C. J. appl. Physiol. 43, 795–800 (1977).

    CAS  PubMed  Google Scholar 

  45. Sulzman, F. M., Fuller, C. A. & Moore-Ede, M,. C. Physiol. Behav. 18, 775–779 (1977).

    CAS  PubMed  Google Scholar 

  46. Sulzman, F. M., Fuller, C. A. & Moore-Ede, M. C. Am. J. Physiol. 234, R130–R135 (1978).

    CAS  PubMed  Google Scholar 

  47. Ehret, C. F., Groh, K. R. & Meinert, H. C. Adv. exp. Med. Biol. 108, 185–213 (1978).

    CAS  PubMed  Google Scholar 

  48. Graeber, R. C., Cuthbert, B. N., Sing, H. L., Schneider, R. J. & Sessions, G. R. Proc. XIV int. Conf. int. Soc. Chronobiol. (II Ponte, Milan, 1979).

  49. Block, G. D. & Page, T. L. A. Rev. Neurosci. 1, 19–34 (1978).

    CAS  Google Scholar 

  50. Menaker, M., Takahashi, J. S. & Eskin, A. A. Rev. Physiol. 40, 501–526 (1978).

    CAS  Google Scholar 

  51. Kawamura, H. & Ibuka, N. Chronobiologica 5, 69–88 (1978).

    CAS  Google Scholar 

  52. Rusak, B. & Zucker, I. Physiol. Rev. 51, 449–526 (1979).

    Google Scholar 

  53. Suda, M., Hayaishi, O. & Nakagawa, H. Biological Rhythms and Their Central Mechanism (Elsevier, Amsterdam, 1979).

    Google Scholar 

  54. Aschoff, J., Groos, G. A. & Wehr, T. A. Vertebrate Circadian Systems: Structure and Physiology (Springer, Berlin, 1982).

    Google Scholar 

  55. Moore, R. Y. & Eichler, V. B. Brain Res. 42, 201–206 (1972).

    CAS  PubMed  Google Scholar 

  56. Moore, R. Y. in The Neurosciences: Third Study Program (eds Schmitt, F. O. & Worden, F. G.) 537–542 (MIT Press, Cambridge, Massachusetts, 1974).

    Google Scholar 

  57. Moore, R. Y. Front Neuroendocr. 5, 185–206 (1978).

    ADS  CAS  Google Scholar 

  58. Stephan, F. K. & Zucker, I. Physiol. Behav. 8, 315–326 (1972).

    CAS  PubMed  Google Scholar 

  59. Stephan, F. K. & Zucker, I. Proc. natn. Acad. Sci. U.S.A. 69, 1583–1586 (1972).

    ADS  CAS  Google Scholar 

  60. Lydic, R., Schoene, W. C., Czeisler, C. A. & Moore-Ede, M. C. Sleep 2, 355–361 (1980).

    CAS  PubMed  Google Scholar 

  61. Nichino, H., Koizumi, K. & Brooks, C. M. Brain Res. 112, 45–59 (1976).

    Google Scholar 

  62. Groos, G. A. & Mason, R. Neurosci. Lett. 8, 59–64 (1978).

    CAS  PubMed  Google Scholar 

  63. Groos, G. A. & Mason, R. J. comp. Physiol. 135, 349–356 (1980).

    Google Scholar 

  64. Sawaki, Y. Expl Brain Res. 37, 127–138 (1979).

    CAS  Google Scholar 

  65. Mai, J. K. J. Hirnforsch. 19, 213–288 (1978).

    CAS  PubMed  Google Scholar 

  66. Groos, G. A. Preprint (1981).

  67. Inouye, S. T. & Kawamura, H. Proc. natn. Acad. Sci. U.S.A. 76, 5962–5966 (1979).

    ADS  CAS  Google Scholar 

  68. Scwartz, W. J. & Gainer, H. Science 197, 1089–1091 (1977).

    ADS  Google Scholar 

  69. Schwartz, W. J., Smith, C. B. & Davidsen, L. in Biological Rhythms and Their Central Mechanism (eds Suda, M., Hayaishi, O. & Nakagawa, H.) 355–364 (Elsevier, Amsterdam, 1979).

    Google Scholar 

  70. Schwartz, W. J., Davidson, L. C. & Smith, C. B. J. comp. Neurol. 189, 157–167 (1980).

    CAS  PubMed  Google Scholar 

  71. Perlow, M. J., Reppert, S. M., Tamarkin, L., Wyatt, R. J. & Klein, D. C. Brain Res. 182, 211–216 (1980).

    CAS  PubMed  Google Scholar 

  72. Richter, C. P. Johns Hopkins med. J. 141, 47–61 (1977).

    CAS  PubMed  Google Scholar 

  73. Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A. & Markey, S. P. Science 210, 1267–1269 (1980).

    ADS  CAS  PubMed  Google Scholar 

  74. Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A. & Rosenthal, N. E. Lancet i, 383–384 (1981).

    Google Scholar 

  75. Klein, K. E. & Wegmann, H. M. in Chronobiology (eds Scheving, L., Halberg, F. & Pauly, J.) 564–570 (Thieme, Stuttgart, 1974).

    Google Scholar 

  76. Halberg, F. Symp. Bel-Air III, 73–126 (Masson & Cie, Geneva, 1968).

  77. Dirlich, G., Kammerlo, A., Schulz, H., Lund, R., Doerr, P. & Vonzerss, P. Biol. Psychiat. 16, 163–179 (1981).

    CAS  PubMed  Google Scholar 

  78. Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W. & Gillin, J. C. Science 206, 710–713 (1979).

    ADS  CAS  PubMed  Google Scholar 

  79. Wehr, T. A., Goodwin, F. K., Wirz-Justice, A. & Craig, C. Archs gen. Psychiat. (in the press).

  80. Wehr, T. A. & Goodwin, F. K. Am. Handbk Psychiat. 7, 46–74 (1981).

    Google Scholar 

  81. Lewy, A. J., Kern, H. E., Rosenthal, N. E. & Wehr, T. A., Goodwin, F. K. Am. J. Psychiat. (submitted).

  82. Lewy, A. J. & Newsome, D. A. New Engl. J. Med. (submitted).

  83. Pauly, J. E., Scheving, L., Burns, E. R., Landon, J. & Stone, J. E. Proc. XII int. Conf. int. Soc. Chronobiol. 19–28 (II Ponte, Milan, 1977).

  84. Sieber, W. thesis, Univ. Munich (1976).

  85. Elliott, A. L., Mills, J. N. & Waterhouse, J. M. J. Physiol., Land. 212, 30–31 (1971).

    Google Scholar 

  86. Weber, A. L., Keyes, P., Conner, N. & Cary, M. S. Sleep 2, 347–354 (1980).

    CAS  PubMed  Google Scholar 

  87. Miles, L. E. M., Raymal, D. M. & Wilson, M. R. Science 198, 421–423 (1977).

    ADS  CAS  PubMed  Google Scholar 

  88. Kokkoris, C. P. et al. Sleep 1, 177–190 (1978).

    CAS  PubMed  Google Scholar 

  89. Wever, R. Pflüger's Arch. (submitted).

  90. Weitzman, E. D. et al. Archs gen. Psychiat. 38, 737–746 (1981).

    CAS  Google Scholar 

  91. Czeisler, C. A. et al. Sleep 4, 1–21 (1981).

    CAS  PubMed  Google Scholar 

  92. Moore-Ede, M. C. The Clocks That Time Us: Structure and Function of the Circadian Timing System (Harvard University Press, 1982).

    Google Scholar 

  93. Monk, T. H. & Aplin, L. C. Ergonomics 23, 167–178 (1980).

    CAS  PubMed  Google Scholar 

  94. Klein, K. E. & Wegmann, H. M. in NATO-AGARD-AG-247 (Technical Editing and Reproduction Ltd, London, 1980).

  95. Aschoff, J., Hoffman, K., Pohl, H. & Wever, R. Chronobiologica 2, 23–78 (1975).

    CAS  Google Scholar 

  96. Wever, R. Chronobiologica 7, 303–327 (1981).

    Google Scholar 

  97. Aschoff, J. & Wever, R. Handbk behav. Neurobiol. 4, 311–331 (1981).

    Google Scholar 

  98. Hume, K. I. Sleep 2, 417–435 (1980).

    CAS  PubMed  Google Scholar 

  99. Wever, R. in Biological Rhythms in Sleep and Shift-work (eds Johnson, L. C, Tepas, D. J., Colquhoun, W. P. & Colligan, M. J.) 35–60 (Spectrum, New York. 1981).

    Google Scholar 

  100. Reinberg, A., Vieux, N. & Andlauer, P. Adv. Biosci. 30 (1981).

  101. Johnson, L. C., Tepas, D. I., Colquhoun, W., C. & Colligan, J. Advances in Sleep Research Vol. 7 (Spectrum, New York, 1981).

    Google Scholar 

  102. Reinberg, A. Vieux, N., Ghata, J., Chaumont, A. J. & Laporte, A. J. Physiol., Paris 74, 405–409 (1978).

    CAS  Google Scholar 

  103. Scheving, L. E. & Pauly, J. E. Chronobiologica 1, 3–21 (1974).

    CAS  Google Scholar 

  104. Halberg, F. Hosp. Pract. 12, 139–149 (1977).

    CAS  PubMed  Google Scholar 

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  1. Department of Biological Science, Purdue University,

    Arthur T. Winfree

  2. Institute of Natural Philosophy, West Lafayette, Indiana, 47906, USA

    Arthur T. Winfree

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Winfree, A. Human body clocks and the timing of sleep. Nature 297, 23–27 (1982). https://doi.org/10.1038/297023a0

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