Abstract
We have previously established the presence of a gene in mice (called Lus)1 which is dominant for the suppression of cytostasis, an experimental assay of cell-mediated immunity2. Here we describe the definition of a gene (segregating independently of Lus) that, in combination with the dominant gene Lusa, is homozygous recessive for a lymphoid hyperplastic disorder of T and B cells. We have called this gene Arp. The disease involves abnormalitities of lymphopoietic and other organs, and could be a model system for regulatory defects of the immune system.
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References
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DeGiorgi, L., Matossian-Rogers, A. & Festenstein, H. Two genes interact to control development of a lymphoid/erythroid hyperplastic disorder of mice. Nature 292, 545–547 (1981). https://doi.org/10.1038/292545a0
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DOI: https://doi.org/10.1038/292545a0
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