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An immunoglobulin heavy-chain gene is formed by at least two recombinational events

Nature volume 283, pages 733–739 (1980)Cite this article

Abstract

The events of B-cell differentiation can be reconstructed in part through an analysis of the organisation of heavy-chain gene segments in differentiated B cells. A mouse immunoglobulin α heavy-chain gene is composed of at least three noncontiguous germ-line DNA segments—a VH gene segment, a JH gene segment associated with the Cμ gene segment, and the Cα gene segment. These gene segments are joined together by two distinct types of DNA rearrangements—a V–J joining and a CH switch.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125

    Mark M. Davis, Kathryn Calame, Philip W. Early, Donna L. Livant & Leroy Hood

  2. Laboratory of Experimental Oncology, Department of Pathology, Stanford Medical School, Stanford, California, 94305

    Rolf Joho & Irving L. Weissman

Authors
  1. Mark M. Davis
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  2. Kathryn Calame
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  3. Philip W. Early
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  4. Donna L. Livant
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  5. Rolf Joho
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  6. Irving L. Weissman
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  7. Leroy Hood
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Davis, M., Calame, K., Early, P. et al. An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature 283, 733–739 (1980). https://doi.org/10.1038/283733a0

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