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Three-receptor, clonal expansion model for selection of self-recognition in the thymus

Nature volume 283, pages 527–532 (1980)Cite this article

Abstract

The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.

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References

  1. Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).

    Article  ADS  CAS  Google Scholar 

  2. Shearer, G. M., Rhem, T. G. & Garbarino, C. A. J. exp. Med. 141, 1348–1364 (1975).

    Article  CAS  Google Scholar 

  3. Bevan, M. J. J. exp. Med., 142, 1349–1364 (1975).

    Article  CAS  Google Scholar 

  4. Shevach, E. M. & Rosenthal, A. S. J. exp. Med. 138, 1213–1227 (1973).

    Article  CAS  Google Scholar 

  5. Katz, D. H. & Benacerraf, B. Transplantn Rev. 22, 175–195 (1975).

    CAS  Google Scholar 

  6. Bechtol, K. B., Freed, J. H., Herzenberg, L. A. & McDevitt, H. O. J. exp. Med. 140, 1660–1675 (1974).

    Article  CAS  Google Scholar 

  7. von Boehmer, H., Hudson, L. & Sprent, J. J. exp. Med. 142, 989–997 (1975).

    Article  CAS  Google Scholar 

  8. Katz, D. H. Cold Spring Harb. Symp. quant. Biol. 41, 611–624 (1976).

    Article  Google Scholar 

  9. Doherty, P. C. Immunogenetics 3, 517–524 (1976).

    Article  Google Scholar 

  10. Bevan, M. J. Cold Spring Harb. Symp. quant. Biol. 41, 519–527 (1976).

    Article  Google Scholar 

  11. von Boehmer, H., Haas, W. & Jerne, N. K. Proc. natn. Acad. Sci. U.S.A. 75, 2439–2442 (1978).

    Article  ADS  CAS  Google Scholar 

  12. Bevan, M. J. Nature 269, 417–419 (1977).

    Article  ADS  CAS  Google Scholar 

  13. Zinkernagel, R. M., Callahan, G. N., Klein, J. & Dennert, G. Nature 271, 251–253 (1978).

    Article  ADS  CAS  Google Scholar 

  14. Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1978).

    Article  CAS  Google Scholar 

  15. Jerne, N. K. Eur. J. Immun. 1, 1–9 (1971).

    Article  CAS  Google Scholar 

  16. Bodmer, W. F. Nature 237, 139–145 (1972).

    Article  ADS  CAS  Google Scholar 

  17. Sprent, J. J. exp. Med. 147, 1159–1174 (1978).

    Article  CAS  Google Scholar 

  18. Cohn, M. & Epstein, R. Cell. Immun. 39, 125–153 (1978).

    Article  CAS  Google Scholar 

  19. Janeway, C. A., Jr, Binz, H. & Wigzell, H. Scand. J. Immun. 5, 993–1001 (1976).

    Article  CAS  Google Scholar 

  20. Rabbits, T. M. & Forster, A. Cell 13, 319–327 (1978).

    Article  Google Scholar 

  21. Lenhart-Schuller, R., Hohn, B., Brack, C., Hirama, M. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 74, 4709–4713 (1978).

    Article  ADS  Google Scholar 

  22. Seidman, J. & Leder, P. Nature 276, 790–795 (1978).

    Article  ADS  CAS  Google Scholar 

  23. Deiner, E. & Water, C. A. in T and B Lymphocytes: Recognition and Function (eds Bonavida, B., Vitetta, E. & Bach, F. Academic, New York, in the press).

  24. Matzinger, P. & Mirkwood, G. J. exp. Med. 148, 84–92 (1978).

    Article  CAS  Google Scholar 

  25. Blanden, R. V. & Kees, U. J. exp. Med. 147, 1661–1670 (1978).

    Article  CAS  Google Scholar 

  26. Cantor, H. & Boyse, E. A. J. exp. Med. 141, 1376–1389 (1975).

    Article  CAS  Google Scholar 

  27. Cantor, H. & Boyse, E. A. J. exp. Med. 141, 1390–1399 (1975).

    Article  CAS  Google Scholar 

  28. Zinkernagel, R. M. & Doherty, P. C. J. exp. Med. 141, 1427–1436 (1975).

    Article  CAS  Google Scholar 

  29. Blank, K. & Lilley, F. Nature 269, 808–809 (1977).

    Article  ADS  CAS  Google Scholar 

  30. Hurme, M., Hetherington, C. M., Chandler, P. R., Gordon, R. D. & Simpson, E. Immunogenetics 5, 453–459 (1977).

    Article  Google Scholar 

  31. Ching, L-M. & Marbrook, J. Eur. J. Immun, 9, 22–27 (1979).

    Article  CAS  Google Scholar 

  32. Simonsen, M. Cold Spring Harb. Symp. quant. Biol. 32, 517–523 (1968).

    Article  Google Scholar 

  33. Wilson, D. B., Blyth, J. & Nowell, P. C. J. exp. Med. 128, 1157–1181 (1968).

    Article  CAS  Google Scholar 

  34. Bach, F. M., Bock, H., Graupner, K., Day, E. & Klostermann, H. Proc. natn. Acad. Sci. U.S.A. 62, 377–384 (1969).

    Article  ADS  CAS  Google Scholar 

  35. Skinner, M. A. & Marbrook, J. J. exp. Med. 143, 1562–1567 (1976).

    Article  CAS  Google Scholar 

  36. Bevan, M. J., Langman, R. & Cohn, M. Eur. J. Immun. 6, 150–156 (1976).

    Article  CAS  Google Scholar 

  37. Lindahl, K. F. & Wilson, D. B. J. exp. Med. 145, 508–522 (1977).

    Article  CAS  Google Scholar 

  38. Teh, H-S., Harley, E., Phillips, R. A. & Miller, R. G. J. Immun. 118, 1049–1056 (1977).

    CAS  PubMed  Google Scholar 

  39. Brondz, B. D. Transplantn Rev. 10, 112–151 (1972).

    CAS  Google Scholar 

  40. Ford, W. L. & Atkins, R. C. Nature new Biol. 234, 178–180 (1972).

    Article  Google Scholar 

  41. Lefkovits, I. Curr. Topics Microbiol. Immun. 65, 21–58 (1974).

    CAS  Google Scholar 

  42. Wilson, D. B. in Progress in Immunology II, 2 (eds Brent, L. & Holbrow, J.) 145 (1974).

    Google Scholar 

  43. Binz, H. & Wigzell, H. Cold Spring Harb. Symp. quant. Biol. 41, 275–284 (1976).

    Article  Google Scholar 

  44. Krawinkel, U. et al. Cold Spring Harb. Symp. quant. Biol. 41, 285–294 (1976).

    Article  Google Scholar 

  45. Jerne, N. K., Annals Immun., Paris 125C, 373–389 (1974).

    CAS  Google Scholar 

  46. Sege, K. & Paterson, P. A. Nature 271, 167–168 (1978).

    Article  ADS  CAS  Google Scholar 

  47. Binz, H. & Wigzell, H. J. exp. Med. 142, 1218–1230 (1975).

    Article  CAS  Google Scholar 

  48. Eichmann, K. Adv. Immun. 26, 195–254 (1978).

    Article  ADS  CAS  Google Scholar 

  49. Langman, R. E. Rev. Physiol. Biochem. Pharmac. 81, 1–37 (1978).

    Article  CAS  Google Scholar 

  50. Kees, U., Müllbacher, A. & Blanden, R. V. J. exp. Med. 148, 1711–1715 (1978).

    Article  CAS  Google Scholar 

  51. Meo, T., Vives, J., Miggiano, B. & Shreffler, D. Transplantn Proc. 5, 377–381 (1973).

    CAS  Google Scholar 

  52. Festenstein, H. Transplantn Rev. 15, 62–88 (1973).

    CAS  Google Scholar 

  53. Forman, J. & Klein, J. Immunogenetics 1, 469–481 (1975).

    Article  Google Scholar 

  54. Benacerraf, B. & McDevitt, H. O. Science 175, 273–279 (1972).

    Article  ADS  CAS  Google Scholar 

  55. Hammerling, G. J. & McDevitt, H. O. J. Immun. 112, 1726–1733 (1974).

    CAS  PubMed  Google Scholar 

  56. Ebringer, A., Deacon, N. L. & Young, C. R. J. Immunogenetics 3, 401–409 (1976).

    Article  CAS  Google Scholar 

  57. Kappler, J. W. & Marrack, P. J. exp. Med. 148, 1510–1522 (1978).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry, University of Glasgow, UK

    A. R. Williamson

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  1. A. R. Williamson
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Williamson, A. Three-receptor, clonal expansion model for selection of self-recognition in the thymus. Nature 283, 527–532 (1980). https://doi.org/10.1038/283527a0

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