Abstract
Since its actions on smooth muscle were first described by von Euler and Gaddum1, substance P has been isolated and characterised as an undecapeptide2,3. The distribution of substance P-like immunoreactivity in both the central and peripheral nervous systems4,5 and its reported excitatory action on neurones implicate substance P as a possible neurotransmitter and/or neuromodulator6,7. Previous studies using bioassay8,9 and radioimmunoassay10,11 techniques have reported substance P in retinal extracts. Here we describe the specific immuno-histochemical localisation of substance P-like immunoreactivity in a population of morphologically distinct amacrine cells of the pigeon retina. The localisation of substance P-like immunoreactivity and the recent localisation of enkephalin-like12,13 and somatostatin-like immunoreactivity14 in other types of amacrine cells suggest that the neuropeptides have a specific role in retinal function.
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References
von Euler, U. S. & Gaddum, J. H. J. Physiol., Lond. 72, 74–78 (1931).
Chang, M. M. & Leeman, S. E. J. biol. Chem. 245, 4784–4790 (1970).
Chang, M. M. & Leeman, S. E. & Niall, H. D. Nature new Biol. 232, 86–87 (1971).
Ljungdhl, A., Hokfelt, T. & Nilsson, G. Neuroscience 3, 861–943 (1978).
Cuello, A. C. & Kanazawa, I. J. Comp. Neurol. 178, 129–156 (1978).
Iversen, L. L. & Nicoll, R. A. & Vale, W. W. Neurosci. Res. Prog. Bull. 16, 211–370 (1978).
Barker, J. L. in Peptides in Neurobiology (ed. Gainer, H.) 295–343 (Plenum, New York, 1977).
Duner, H., von Euler, U. S. & Pernow, B. Acta physiol. scand. 31, 113–118 (1954).
Winder, A. F. & Patsalos, P. N. Biochem. Soc. Trans. 4, 1260–1261 (1978).
Kanazawa, I. & Jessel, T. Brain Res. 117, 362–367 (1976).
Reubi, J. C. & Jessel, T. M. J. Neurochem. 31, 359–361 (1978).
Brecha, N. C. & Karten, H. J. Invest. Opthal. visual Sci. 18, Suppl.85 (1979).
Brecha, N., Karten, H. J. & Laverack, C. Proc. natn. Acad. Sci. U.S.A. 76, 3010–3014 (1979).
Marshak, D. W., Yamada, T., Basinger, S. F., Walsh, J. H. & Stell, W. K. Invest. Ophthal. visual Sci. 18, Suppl. 85 (1979).
Cajal, S. R. La Cellule 9, 17–257 (1982).
Karten, H. J., Fite, K. V. & Brecha, N. Proc. natn. Acad. Sci. U.S.A. 74, 1753–1756 (1977).
Hauschild, D. C. & Laties, A. M. Invest. Ophthal. 12, 537–540 (1973).
Ehinger, B. in Transmitters in the Visual Process (ed. Bonting, S. L.) 145–163 (Pergamon, Oxford, 1976).
Galifret, Y. Z. Zellforsch, mikrosk. Anat. 86, 535–545 (1968).
Bonting, S. L. (ed.) in Transmitters in the Visual Process (Pergamon, Oxford, 1976).
Marc, R. E., Stell, W. K., Bok, D. & Lam, D. M. K. J. comp. Neurol. 182, 221–246 (1978).
Baughman, R. W. & Bader, C. R. Brain Res. 138, 469–485 (1977).
Kramer, S. G., Potts, A. M. & Mangnall, Y. Invest. Ophthal. 10, 617–624 (1971).
Lake, N. & Patel, Y. C. Invest. Ophthal. visual Sci. 18, Suppl. 54 (1979).
Shapiro, B., Kronheim, S. & Pimstone, B. Horm. Metab. Res. 11, 79–80 (1979).
Jackson, I. M. D. & Reichlin, S. Science 198, 414–415 (1977).
Schaeffer, J. M. & Brownstein, M. J. Proc. natn. Acad. Sci. U.S.A. 74, 3579–3581 (1977).
Youngblood, W. W., Humm, J. & Kizer, J. S. Brain Res. 163, 101–110 (1979).
Cuello, A. C., Galfre, G. & Milstein, C. Proc. natn. Acad. Sci. U.S.A. 76, 3532–3536 (1979).
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Karten, H., Brecha, N. Localisation of substance P immunoreactivity in amacrine cells of the retina. Nature 283, 87–88 (1980). https://doi.org/10.1038/283087a0
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DOI: https://doi.org/10.1038/283087a0
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