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Bombesin suppresses feeding in rats

Nature volume 282, pages 208–210 (1979)Cite this article

Abstract

Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2–5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7–9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

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Authors and Affiliations

  1. Department of Psychiatry, Cornell University Medical College, Bourne Laboratory, The New York Hospital, White Plains, New York, 10605

    J. Gibbs & D. J. Fauser

  2. Department of Experimental Psychology, University of Oxford, Oxford, UK

    E. A. Rowe, B. J. Rolls, E. T. Rolls & S. P. Maddison

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  1. J. Gibbs
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  2. D. J. Fauser
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  3. E. A. Rowe
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  4. B. J. Rolls
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  5. E. T. Rolls
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  6. S. P. Maddison
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Gibbs, J., Fauser, D., Rowe, E. et al. Bombesin suppresses feeding in rats. Nature 282, 208–210 (1979). https://doi.org/10.1038/282208a0

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