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A structurally abnormal insulin causing human diabetes

Nature volume 281, pages 122–125 (1979)Cite this article

Abstract

Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.

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Authors and Affiliations

  1. Departments of Biochemistry and Medicine, The University of Chicago, Chicago, Illinois, 60637

    H. Tager, B. Given, D. Baldwin, M. Mako, J. Markese & A. Rubenstein

  2. Department of Medicine, The University of Colorado, Denver, Colorado, 80262

    J. Olefsky, M. Kobayashi & O. Kolterman

  3. 1201 West Laueta Street, Orange, California, 92668

    R. Poucher

Authors
  1. H. Tager
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  2. B. Given
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  3. D. Baldwin
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  4. M. Mako
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  5. J. Markese
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  6. A. Rubenstein
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  7. J. Olefsky
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  8. M. Kobayashi
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  9. O. Kolterman
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  10. R. Poucher
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Tager, H., Given, B., Baldwin, D. et al. A structurally abnormal insulin causing human diabetes. Nature 281, 122–125 (1979). https://doi.org/10.1038/281122a0

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