Abstract
TUMOURS of antibody-secreting B lymphocytes (myeloma tumours) have contributed greatly to our understanding of antibody structure and function. T-lymphocyte tumours that retain effector activities might, if they exist, prove to be similarly useful for analysing T cells and their key components. The recent finding that a T lymphoma is capable of crawling on other cells, like antigen-activated normal T lymphocytes1, prompted us to investigate whether some lymphocytic tumour cells can, like normal cytotoxic T lymphocytes, lyse target cells. We report here that they can.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chang, T. W., Celis, E., Eisen, H. N. & Solomon, F. Proc. natn. Acad. Sci. U.S.A. 76, 2917–2921 (1979).
Green, W. R., Ballas, Z. K. & Henney, C. S. J. Immun. 121, 1566–1572 (1978).
Greenberg, R. S., Mathieson, B. J., Campbell, P. S. & Zatz, M. M. J. Immun. 118, 1181–1190 (1977).
Boyse, E. A. & Old, L. J. Harvey Lect. 71, 23–53 (1978).
Sachs, D. H. Contemp. Topics molec. Immun. 5, 1–33 (1976).
Marshak-Rothstein, A. et al. J. Immun. 122, 2491–2497 (1979).
Bevan, M. J. & Cohn, M. J. Immun. 114, 559–565 (1975).
Gately, M. K. & Martz, E. J. Immun. 119, 1711–1722 (1977).
Rubens, R. P. & Henney, C. S. J. Immun. 118, 180–186 (1977).
Kohler, G. & Milstein, C. Nature 256, 495–497 (1975).
Gillis, S. & Smith, K. A. Nature 268, 154–156 (1977).
Dennert, G. Nature 277, 476–477 (1979).
Russell, J. H., Ginns, L. C., Terres, G. & Eisen, H. N. J. Immun. 122, 912–919 (1979).
Lin, J. S. L., Huber, N. & Murphy, W. H. Cancer Res. 29, 2157–2162 (1969).
Chesebro, B., Wehryl, K., Chesebro, K. & Portis, J. J. Immun. 117, 1267–1274 (1976).
Law, L. W., Dunn, T. B., Boyle, P. J. & Miller, J. H. J. natn. Cancer Inst. 10, 179–192 (1949).
Potter, M. Ann. N.Y. Acad. Sci. 76, 630–642 (1958).
Potter, M. & Briggs, G. M. J. natn. Cancer Inst. 28, 341–351 (1962).
Dunn, T. B. & Potter, M. J. natn. Cancer Inst. 18, 587–601 (1957).
Roberts, DeW., Wodinsky, I. & Hall, T. C. Cancer Res. 25, 1899–1903 (1965).
Old, L. J., Boyse, E. A. & Stockert, E. Cancer Res. 25, 813–819 (1965).
Dunham, L. J. & Stewart, H. L. J. natn. Cancer Inst. 13, 1299–1377 (1953).
Ralph, P. J. Immun. 110, 1470–1475 (1973).
Gorer, P. A. Br. J. Cancer 4, 372–379 (1950).
Sato, K., Boyse, E. A., Aoki, T., Iritani, C. & Old, L. J. J. exp. Med. 138, 593–606 (1973).
Arnstein, P., Riggs, J. L., Oshiro, L. S., Huebner, R. J. & Lennette, E. H. J. natn. Cancer Inst. 57, 1085–1090 (1976).
Durda, P. J., Boos, S. C. & Gottlieb, P. D. J. Immun. 122, 1407–1412 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHANG, T., EISEN, H. Lymphomas with cytotoxic activity. Nature 280, 406–408 (1979). https://doi.org/10.1038/280406a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/280406a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.