Abstract
Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.
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Saeed, S., McDonald-Gibson, W., Cuthbert, J. et al. Endogenous inhibitor of prostaglandin synthetase. Nature 270, 32–36 (1977). https://doi.org/10.1038/270032a0
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DOI: https://doi.org/10.1038/270032a0
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