Abstract
ALTERED mucosal penetrability for food constituents and microbial components probably underlies the pathogenesis of a variety of diseases occurring in mucous membranes and distant sites such as liver and joints1. The secretory immune system seems to be of major importance in mucosal exclusion of foreign material and is stimulated by topical antigens2. Conversely, parenteral immunisation almost exclusively gives rise to circulating antibodies which are chiefly of the IgG class. IgG is not a secretory immunoglobulin in man, monkey, rabbit and guinea pig3, and contradictory information has been published about the effect of parenteral immunisation on the absorption of antigen through mucous membranes. Moreover, a possible influence on the concurrent mucosal penetration of unrelated macromolecules has not been considered previously. We report here that although serum-derived antibody retards the penetration of corresponding antigen, it nevertheless causes impairment of the mucosal barrier. Induction of IgG antibodies may thus cause hazardous side effects by altering mucosal penetrability.
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BRANDTZAEG, P., TOLO, K. Mucosal penetrability enhanced by serum-derived antibodies. Nature 266, 262–263 (1977). https://doi.org/10.1038/266262a0
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DOI: https://doi.org/10.1038/266262a0
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