Abstract
STUDIES of reactivity to tick bites and tick salivary gland homogenate have revealed responses similar to those induced by histamine in the skin of lop-eared rabbits2. Salivary gland homogenates of the tick Rhipicephalus sanguineus sanguineus, however, did not cause contraction of guinea pig ileum, but blocked the action of histamine acid phosphate (HAP). We have therefore tested this extract against other drugs known to cause contraction of guinea pig ileum in order to discover the spectrum of its blocking effect on this tissue. We have found that the salivary gland homogenate of this tick antagonises and potentiates, respectively, the action of histamine and acetylcholine on guinea pig ileum.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Arthur, D. R., Ticks and Disease, 307–318 (1962).
Chinery, W. A., Exp. Parasit. (in the press).
James, M. T., and Harwood, R. F., Herm's Medical Entomology, 360–361 (1967).
Murnaghan, M. F., Proc. tenth int. Cong. Ent., 3, 841–847 (1958).
Perry, W. L. M., Pharmacological Experiments on Isolated Preparation, (2nd edn), (Livingstone, Edinburgh, London, 1970).
Rose, I., and Gregson, J. D., Nature, 178, 95 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHINERY, W., AYITEY-AMITH, E. Histamine blocking agent in the salivary gland homogenate of the tick Rhipicephalus sanguineus sanguineus. Nature 265, 366–367 (1977). https://doi.org/10.1038/265366a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/265366a0
This article is cited by
-
Specific histamine binding activity of a new lipocalin from Hyalomma asiaticum (Ixodidae) and therapeutic effects on allergic asthma in mice
Parasites & Vectors (2016)
-
The Molecular and Biological Analysis of Ixodid Ticks Histamine Release Factors
Experimental & Applied Acarology (2005)
-
Role of saliva in tick/host interactions
Experimental & Applied Acarology (1989)
-
A putative role for eosinophils in tick rejection
Experientia (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.