Abstract
THE serum protein C1q is a subcomponent of the first component of the complement system. Combination of C1q with antigen–antibody complexes activates the other subcomponents of C1 (C1r and C1s) and sets in motion a series of events which results in activation of the entire complement system. The primary structure of C1q is unusual in that 40% of its amino acid sequence is composed of repeating X-Y-Gly triplets where X is often proline and Y often hydroxyproline or hydroxylysine, indicating a striking similarity to collagen1,2. It has also been proposed that these collagen polypeptide-like stretches in C1q associate in triple helical fashion3. Because of the similarities between these portions of C1q and collagen the present investigation was undertaken to determine whether C1q is synthesised by collagen-producing cells, namely fibroblasts.
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AL-ADNANI, M., O'D McGEE, J. C1q production and secretion by fibroblasts. Nature 263, 145–146 (1976). https://doi.org/10.1038/263145a0
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DOI: https://doi.org/10.1038/263145a0
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