Abstract
THERE has been some controversy for the past few years concerning the inhibitory effect of interferon on cell multiplication. We and others have presented evidence that interferon itself is the responsible factor1–13. Some investigators have, however, failed to observe any inhibition of cell multiplication with interferon preparations14–17; while others have observed inhibition but ascribed this effect to substances other than interferon in their preparations, either because no inhibition was observed when more purified preparations were used18 or because of apparently inconstant ratios between antiviral and cell multiplication inhibitory (CMI) activities in a given preparation19–21. It has been claimed that the factor responsible for the CMI activity of human leukocyte interferon preparations could be physically separated from the factor responsible for the antiviral activity22. We provide strong evidence that the antiviral and CMI activities of interferon preparations are indeed intrinsic properties of the covalent structure of interferons.
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STEWART, W., GRESSER, I., TOVEY, M. et al. Identification of the cell multiplication inhibitory factors in interferon preparations as interferons. Nature 262, 300–302 (1976). https://doi.org/10.1038/262300a0
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DOI: https://doi.org/10.1038/262300a0
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