Abstract
IMMUNOLOGICAL responses to histoincompatible tissues and to tumour cells are mediated by thymus-derived (T) lymphocytes. The cells that effect these responses have been termed cytotoxic T-killer cells and are derived from T-precursor cells that have become programmed (committed) to recognise specific antigenic determinants. The generation of T-effector or killer cells involves the collaboration of two distinct subpopulations of T cells. Helper T cells interact with specific precursor T cells when stimulated by antigen and, during the resultant differentiation processes, the precursor clones mature into specific killer cells1–3. The nature or mechanisms of the collaboration between the precursor and helper T cells has been obscure until now. The data presented here demonstrate that soluble T-cell products can replace the requirement for helper T cells in the generation of T-killer cells. The active substances are produced on antigenic stimulation and are as effective as T-helper cells during the differentiation of precursor T cells into killer cells.
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PLATE, J. Soluble factors substitute for T–T-cell collaboration in generation of T-killer lymphocytes. Nature 260, 329–331 (1976). https://doi.org/10.1038/260329a0
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DOI: https://doi.org/10.1038/260329a0
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