Abstract
SOMATIC cell hybrids have been used to discern many properties of parental cells. Genes for neuronal properties can be activated in hybrids formed by fusion of mouse neuroblastoma and rat glioma cells (refs 1 and 2, and B. Hamprecht, T. Amano and M. Nirenberg, personal communication). These cell hybrids resemble the parent neuroblastoma cells in many of their properties as they can be induced to extend long neurites and possess electrically excitable membranes1. In addition the cell hybrids express other neuronal characteristics that are less pronounced in the parental cells, such as choline acetyltransferase1, and morphine receptors2. Many of the above properties suggest alterations in the surface membrane. We have shown previously that a particular group of glycopeptides is more prominently expressed on the cell surface in clones of mouse neuroblastoma which have the ability to undergo morphological differentiation than in clones that are unable to extend neurites3. In the present report, we show that this group of glycopeptides is abundant in the surface membranes of the hybrid cells.
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References
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GLICK, M., KIMHI, Y. & LITTAUER, U. Surface membrane alterations in somatic cell hybrids of neuroblastoma and glioma cells. Nature 259, 230–232 (1976). https://doi.org/10.1038/259230a0
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DOI: https://doi.org/10.1038/259230a0
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