Abstract
THE ability to separate human peripheral blood T and B lymphocytes has allowed serological identification of specific B cell antigens, and several lines of evidence indicate that these antigens are controlled by a gene or genes of the HLA genetic region1. Van Rood et al. presented evidence for an antigen which seems to be associated with, or closely linked to, the locus responsible for mixed lymphocyte stimulation (HLA-D)2. Our results in family studies suggest that there are a number of specific B-cell alloantigens that are controlled by genes linked closely to genes controlling the expression of HLA alloantigens3,4.
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References
Yunis, E. J., Krivit, W., Reinsmoen, N., and Amos, D. B., Nature, 248, 517–519 (1974).
Van Rood, J. J., van Leenvan, A., Keuning, J. J., and Blusse van Oud Alblas, A., Tissue Antigens, 5, 73–79 (1975).
Mann, D. L., Henkart, P., Abelson, L., Harris, S., and Amos, D. B., Proc. natn. Acad. Sci. U.S.A. (in the press).
Mann, D. L., Abelson, L., Henkart, P., Harris, S., and Amos, D. B., Proc. 6th Int. Histocompatibility Workshop (in the press).
Sachs, D. H., and Cone, J. L., J. exp. Med., 138, 1290–1304 (1973).
Shreffler, D. C., et al., Immunogenetics (in the press).
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MANN, D., ABELSON, L., HARRIS, S. et al. Second genetic locus in the HLA region for human B-cell alloantigens. Nature 259, 145–146 (1976). https://doi.org/10.1038/259145a0
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DOI: https://doi.org/10.1038/259145a0
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