Abstract
REDISTRIBUTION of the largely diffuse binding sites on the cell surface of lymphocytes and many other cell types into clusters, or into highly polarised single aggregates or caps1, is induced by interaction with divalent or poly valent ligands such as antibodies, lectins or ligand-conjugated macromolecules2. Capping has been used as evidence for the fluid mosaic model of membrane structure3 and it has been observed in various cell types, it may be a general property of animal cells4. An interesting exception has been the cell surface of the adult human red blood cell, which does not show clustering or capping with antibodies and lectins5. We have now demonstrated redistribution of fluorescent labelled polycations on the surface of erythrocytes fixed with glutaraldehyde or formalin when polyanions are added.
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LARSEN, B. Redistribution of surface-bound polyelectrolytes on erythrocytes. Nature 258, 344–345 (1975). https://doi.org/10.1038/258344a0
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DOI: https://doi.org/10.1038/258344a0
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