Abstract
THE major histocompatibility complex in the mouse encompasses several distinct loci, which, with one exception, control the expression of cell surface glycoproteins. The exception is the Ss-S1p traits1. The Ss trait involves regulation of the level of a plasma protein, the Ss protein2. The S region of the H–2 complex, whose marker gene controls the Ss-protein concentration, also regulates the haemolytic complement level3. This has led to the suggestion that the Ss protein is a component of complement3,4. We have isolated the Ss protein and demonstrate here that it is the murine equivalent of C4.
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CURMAN, B., ÖSTBERG, L., SANDBERG, L. et al. H–2 linked Ss protein is C4 component of complement. Nature 258, 243–245 (1975). https://doi.org/10.1038/258243a0
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DOI: https://doi.org/10.1038/258243a0
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