Abstract
The functional implications of the different modes of regulation have been examined systematically. The results lead to certain predictions. The regulatory protein in repressor-controlled systems is constitutively synthesised. In activator-controlled systems synthesis of the regulatory protein is autogenously regulated. There is favourable agreement between these predictions and published experimental evidence.
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References
Reznikoff, W. S., A. Rev. Genet., 6, 133–156 (1972).
Savageau, M. A., Nature, 252, 546–549 (1974).
Hershey, A. D. (ed.), The Bacteriophage Lambda (Cold Spring Harbor Laboratory, New York, 1971).
Jacob, F., and Monod, J., J. molec. Biol., 3, 318–356 (1961).
Zubay, G., Morse, D. E., Schrenk, W. J., and Miller, J. H. M., Proc. natn. Acad. Sci. U.S.A., 69, 1100–1103 (1972).
Squires, C. L., Rose, J. K., Yanofsky, C., Yang, H.-L., and Zubay, G., Nature new Biol., 245, 131–133 (1973).
Rose, J. K., Squires, C. L., Yanofsky, C., Yang, H.-L., and Zubay, G., Nature new Biol., 245, 133–137 (1973).
McGeoch, D., McGeoch, J., and Morse, D., Nature new Biol., 245, 137–140 (1973).
Zalkin, H., Yanofsky, C., and Squires, C. L., J. biol. Chem., 249, 465–475 (1974).
Shimizu, N., Shimizu, Y., Fujimura, F. K., and Hayashi, M., FEBS Lett., 40, 80–83 (1974).
Udaka, S., Nature, 228, 336–338 (1970).
Urm, E., Yang, H., Zubay, G., Kelker, N., and Maas, W., Molec. gen. Genet., 121, 1–7 (1973).
Brenner, M., and Ames, B. N., in Metabolic Pathways, third ed. (edit. by Vogel, H. J.), 5, 349–387 (Academic, New York, 1971).
DeLorenzo, F., and Ames, B. N., J. biol. Chem., 245, 1710–1716 (1970).
DeLorenzo, F., Straus, D. S., and Ames, B. N., J. biol. Chem., 247, 2302–2307 (1972).
Wyche, J. H., Ely, B., Cebula, T. A., Snead, M. C., and Hartman, P. E., J. Bact., 117, 708–716 (1974).
Kovach, J. S., et al., J. Bact., 104, 787–792 (1970).
Blasi, F., Barton, R. W., Kovach, J. S., and Goldberger, R. F., J. Bact., 106, 508–513 (1971).
Goldberger, R. F., and Kovach, J. S., Curr. Top. Cell. Reg., 5, 285–308 (1972).
Rothman-Denes, L., and Martin, R. G., J. Bact., 106, 227–237 (1971).
Blasi, F., et al., Proc. natn. Acad. Sci. U.S.A., 70, 2692–2696 (1973).
Artz, S. W., and Broach, J. R., Proc. natn. Acad. Sci. U.S.A. (in the press).
Freundlich, M., Burns, R. O., and Umbarger, H. E., Proc. natn. Acad. Sci. U.S.A., 48, 1804–1808 (1962).
Freundlich, M., Biochem. biophys. Res. Commun., 10, 277–282 (1963).
Umbarger, H. E., in Metabolic Pathways, third ed. (edit. by Vogel, H. J.), 5, 447–462 (Academic, New York, 1971).
Hatfield, G. W., and Burns, R. O., Proc. natn. Acad. Sci. U.S.A., 66, 1027–1035 (1970).
Calhoun, D. H., and Hatfield, G. W., Proc. natn. Acad. Sci. U.S.A., 70, 2757–2761 (1973).
Levinthal, M., Williams, L., Levinthal, M., and Umbarger, H. E., Nature new Biol., 246, 65–68 (1974).
Avitabile, A., Carlomagno-Cerillo, M. S., Favre, R., and Blasi, F., J. Bact., 112, 40–47 (1972).
Goldberger, R. F., Science, 183, 810–816 (1974).
Savageau, M. A., Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology (Benjamin/Addison-Wesley, Massachusetts, in the press).
Patthy, L., and Denes, G., Acta Biochim. Biophys. Acad. Sci. Hung., 5, 147–157 (1970).
Sonneborn, T. M., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel, H. J.), 377–397 (Academic, London, 1965).
Taylor, A. L., and Trotter, C. D., Bact. Rev., 36, 504–524 (1972).
Vogel, R. H., McLellan, W. L., Hirvonen, A. P., and Vogel, H. J., in Metabolic Pathways, third ed. (edit. by Vogel, H. J.), 5, 463–488 (Academic, New York, 1971).
Bollon, A. P., and Magee, P. T., J. Bact., 113, 1333–1344 (1973).
Bollon, A. P., Nature, 250, 630–634 (1974).
Kline, E. L., Brown, C. S., Coleman, W. G., Jr, and Umbarger, H. E., Biochem. biophys. Res. Commun., 57, 1144–1151 (1974).
Somerville, R. L., and Yanofsky, C., J. molec. Biol., 11, 747–759 (1965).
Stetson, H., and Somerville, R. L. Molec. gen. Genet., 111, 342–351 (1971).
Somerville, R. L., and Stetson, H., Molec. gen. Genet., 131, 247–261 (1974).
Hiraga, S., and Yanofsky, C., Nature new Biol., 237, 47–49 (1972).
Yang, H.-L., Zubay, G., Urm, E., Reiness, G., and Cashel, M., Proc. natn. Acad. Sci. U.S.A., 71, 63–67 (1974).
Kasai, T., Nature, 249, 523–527 (1974).
Bertrand, K., et al., Science, 189, 22–26 (1975).
Sompayrac, L., and Maaløe, O., Nature new Biol., 241, 133–135 (1973).
Dennis, P. P., and Nomura, M., Nature, 255, 460–465 (1975).
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Savageau, M. Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems. Nature 258, 208–214 (1975). https://doi.org/10.1038/258208a0
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DOI: https://doi.org/10.1038/258208a0
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