Abstract
CELL surface proteins specific for either T or B lymphocytes probably have a significant role in lymphocyte physiology, and we have therefore been characterising the plasma membrane proteins from mouse lymphocytes to identify such molecules and to determine their function. We have previously detected a high molecular weight T-cell-surface protein (T200, apparent molecular weight 200,000) which could be labelled by lactoperoxidase-catalysed iodination1 and was recognised by rabbit anti-mouse thymocyte sera (ATS). We have now identified a low molecular weight T-cell-specific molecule present on mouse thymocytes, T lymphomas and peripheral T cells which is also recognised by rabbit antibodies to mouse lymphocytes.
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References
Trowbridge, I. S., Ralph, P., and Bevan, M. J., Proc. natn. Acad. Sci. U.S.A., 72, 157–161 (1975).
Levey, R. H., and Medawar, P. B., Proc. natn. Acad. Sci. U.S.A., 56, 1130–1137 (1966).
Gutman, G., and Weissman, I. L., in Morphological and Fundamental Aspects of Immunity (edit. by Lindahl-Kiessling, K., Alm, G., and Hanna, M.), 595–602 (Plenum, New York, 1971).
Gutman, G. A., and Weissman, I. L., Immunology, 23, 465–479 (1972).
Friedberg, S. H., and Weissman, I. L., J. Immun., 113, 1477–1492 (1974).
Reif, A. E., and Allen, J. M. V., J. exp. Med., 120, 413–433 (1964).
Thiele, H.-G., and Stark, R., Immunology, 27, 807–813 (1974).
Morris, R. J., Letarte-Muirhead, M., and Williams, A. F., Eur. J. Immun., 5, 282–285 (1975).
Hyman, R., and Stallings, V., J. natn. Cancer Inst., 52, 429–436 (1974).
Letarte-Muirhead, M., Acton, R. T., and Williams, A. F., Biochem. J., 143, 51–61 (1974).
Douglas, T. C., Transplant. Proc., 5, 79–82 (1973).
Acton, R. T., Morris, R. J., and Williams, A. F., Eur. J. Immun., 4, 598–602 (1974).
Vitetta, E. S., Boyse, E. A., and Uhr, J. W., Eur. J. Immun., 3, 446–453 (1973).
Esselman, W. J., and Miller, H. C., J. exp. Med., 139, 445–450 (1974).
Watkins, W. M., Science, 152, 172–181 (1966).
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TROWBRIDGE, I., WEISSMAN, I. & BEVAN, M. Mouse T-cell surface glycoprotein recognised by heterologous anti-thymocyte sera and its relationship to Thy-1 antigen. Nature 256, 652–654 (1975). https://doi.org/10.1038/256652a0
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DOI: https://doi.org/10.1038/256652a0
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