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Specific roles for platelet surface glycoproteins in platelet function

Nature volume 255, pages 720–722 (1975)Cite this article

Abstract

THE haemostatic role of the blood platelet is largely dependent on its ability to adhere to exposed subendothelial components in the event of vessel damage1 and respond to specific aggregation-inducing stimuli, such as adenosine diphosphate (ADP), which seem to act at defined receptor sites on the platelet membrane2. The early stages of platelet adhesion and aggregation are surface-mediated phenomena and much interest has centred on determining which of the surface groupings are involved in these mechanisms. Iodination techniques3,4 have revealed that a limited number of proteins are exposed on the surface of the platelet and that among these are the major membrane glycoproteins. A possible involvement of carbohydrate groupings in the mechanisms of aggregation as induced by ADP and 5-hydroxytryptamine was described by Mester et al.5 who showed that the velocity of aggregation was altered by changes in the sialic acid content of the platelet.

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Authors and Affiliations

  1. Nuffield Institute of Comparative Medicine, Zoological Society of London, Regents Park, London, NW1 4RY, UK

    A. T. NURDEN

  2. Department d'Hematologie, Hôpital Lariboisiere, 2, Rue Ambroise Pare, 75010, Paris, France

    J. P. CAEN

Authors
  1. A. T. NURDEN
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  2. J. P. CAEN
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NURDEN, A., CAEN, J. Specific roles for platelet surface glycoproteins in platelet function. Nature 255, 720–722 (1975). https://doi.org/10.1038/255720a0

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