Abstract
LYMPHOID cells sensitised against alloantigens can lyse in vitro target cells bearing these alloantigens1,2. In most of the experimental systems using in vivo sensitised cells, T cells (thymus-dependent lymphocytes) are both necessary3 and sufficient4,5 for induction of target cell lysis. This seems to apply also to in vitro sensitised cells6–9. Specific cytolysis can be described as a two stage process: first, the recognition of target cell antigens by specific receptors at the surface of the ‘killing’ cell10,11; and, second, lysis itself.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Perlmann, P., and Holm, G., Adv. Immun., 11, 117–193 (1969).
Cerottini, J.-C., and Brunner, K. T., Adv. Immun., 18, 67–132 (1974).
Cerottini, J.-C., Nordin, A. A., and Brunner, K. T., Nature, 228, 1308–1309 (1970).
Golstein, P., Wigzell, H., Blomgren, H., and Svedmyr, E. A. J., J. exp. Med., 135, 890–906 (1972).
Golstein, P., and Blomgren, H., Cell. Immun., 9, 127–141 (1973).
Wagner, H., Eur. J. Immun., 1, 498–499 (1971).
Lohmann-Matthes, M.-L., and Fischer, H., Eur. J. Immun., 2, 290–292 (1972).
Andersson, L. C., Nordling, S., and Häyry, P., Scand. J. Immun., 2, 107–113 (1973).
MacDonald, H. R., Phillips, R. A., and Miller, R. G., J. Immun., 111, 575–589 (1973).
Brondz, B. D., Folia Biologica, Prague, 14, 115–131 (1968).
Golstein, P., Svedmyr, E. A. J., and Wigzell, H., J. exp. Med., 134, 1385–1402 (1971).
Ruddle, N. H., and Waksman, B. H., J. exp. Med., 128, 1267–1278 (1968).
Granger, G. A., and Williams, T. W., Nature, 218, 1253–1254 (1968).
Dumonde, D. C., Wolstencroft, R. A., Panayi, G. S., Matthew, M., Morley, J., and Howson, W. T., Nature, 224, 38–42 (1969).
Sabbadini, E., J. Reticuloendothelial Soc., 7, 551–566 (1970).
Hottier, D., Donner, M., and Burg, C., Rev. Eur. Etudes clin. et biol., 16, 240–243 (1971).
Svedmyr, E. A. J., and Hodes, R. J., Cell. Immun., 1, 644–654 (1970).
Canty, T. G., and Wunderlich, J. R., J. nat. Cancer Inst., 45, 761–772 (1970).
Andersson, L. C., and Häyry, P., Cell. Immun., 8, 470–483 (1973).
Cohen, I. R., and Feldman, M., Cell. Immun., 1, 521–535 (1970).
Brunner, K. T., and Cerottini, J.-C., Progr. Immun., 1, 385–398 (1971).
Singh, J. N., Sabbadini, E., and Sehon, A. H., Cell. Immun., 8, 280–289 (1973).
Eife, R. F., and August, C. S., Cell. Immun., 9, 163–168 (1973).
Häyry, P., Andersson, L. C., Nordling, S., and Virolainen, M., Transpln. Rev., 12, 91–140 (1972).
Koren, H. S., Ax, W., and Freund-Moelbert, E., Eur. J. Immun., 3, 32–37 (1973).
Berke, G., Sullivan, K. A., and Amos, D. B., Science, 177, 433–434 (1972).
Heber-Katz, E., and Click, R. E., Cell. Immun., 5, 410–418 (1972).
Bevan, M. J., Epstein, R., and Cohn, M., J. exp. Med., 139, 1025–1030 (1974).
Thorn, R. M., Palmer, J. C., and Manson, L. A., J. Immun. Meth., 4, 301–315 (1974).
Ortiz de Landazuri, M., and Herberman, R. B., Nature new Biol., 238, 18–19 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GOLSTEIN, P. Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity. Nature 252, 81–83 (1974). https://doi.org/10.1038/252081a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/252081a0
This article is cited by
-
An early history of T cell-mediated cytotoxicity
Nature Reviews Immunology (2018)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.