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p53 polymorphism and risk of cervical cancer

Nature volume 396, pages 531–532 (1998)Cite this article

Abstract

Storey and co-workers1 have reported data suggesting that individuals homozygous for arginine at residue 72 of p53 (p53Arg) are about seven times more susceptible to invasive cervical cancer than individuals who carry at least one proline at that position (p53Pro)1. These preliminary data were supported by in vitro evidence demonstrating that the E6 oncoprotein of human papilloma virus (HPV) degrades p53Arg more efficiently than p53Pro. We have now tested specimens from a total of 1,309 women in three studies for p53 polymorphisms. We find that p53Arg is not associated with an increased risk of preinvasive or invasive cervical neoplasia; indeed, there is a tendency for p53Arg to be associated with a decreased risk of neoplasia.

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References

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6130 Executive Boulevard, Bethesda, 20892, Maryland, USA

    Allan Hildesheim, Mark Schiffman, Louise A. Brinton & Joseph F. Fraumeni Jr

  2. International Agency for Research on Cancer, 69372, Lyon, France

    Rolando Herrero

  3. Caja Costarriciense de Seguro Social, San Jose, Costa Rica

    M. Concepcion Bratti

  4. Yale University School of Medicine, New Haven, 06519, Connecticut, USA

    Peter Schwartz

  5. Milton S. Hershey Medical Center, Hershey, 17033, Pennsylvania, USA

    Rodrigue Mortel

  6. Georgetown University Lombardi Cancer Center, Washington, DC 20007, USA

    Willard Barnes

  7. Graduate Hospital, Philadelphia, 19146, Pennsylvania, USA

    Mitchell Greenberg

  8. George Washington University Medical Center, Washington, DC 20037, USA

    Larry McGowan

  9. Kaiser Permanente, Portland, 97227, Oregon, USA

    David R. Scott

  10. Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC, Frederick, 21702, Maryland, USA

    Maureen Martin, Jesus E. Herrera & Mary Carrington

Authors
  1. Allan Hildesheim
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  2. Mark Schiffman
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  3. Louise A. Brinton
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  4. Joseph F. Fraumeni Jr
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  5. Rolando Herrero
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  6. M. Concepcion Bratti
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  7. Peter Schwartz
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  8. Rodrigue Mortel
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  9. Willard Barnes
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  10. Mitchell Greenberg
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  11. Larry McGowan
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  12. David R. Scott
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  13. Maureen Martin
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  14. Jesus E. Herrera
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  15. Mary Carrington
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Cite this article

Hildesheim, A., Schiffman, M., Brinton, L. et al. p53 polymorphism and risk of cervical cancer. Nature 396, 531–532 (1998). https://doi.org/10.1038/25040

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