Abstract
The specific cytolytic activity exhibited in vitro by thymus-derived (T) lymphocyte populations from immune animals (see review in ref. 1), is germane to allograft rejection2,3 and to pathways by which neoplastic tissue can be destroyed in vivo4,5. The mechanism involved, however, remains controversial (for one viewpoint see ref. 6) and the nature of the lytic lesion is unknown.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Perlmann, P., and Holm, G., Adv. Immun., 11, 117 (1969).
Berke, G., Yagil, G., Ginsburg, H., and Feldman, M., Immunology, 17, 723 (1969).
Rouse, B. T., Wagner, H., and Harris, A. W., J. Immun., 109, 1282 (1972).
Freedman, L. R., Cerottini, J-C., and Brunner, K. T., J. Immun., 109, 1371 (1972).
Rouse, B. T., Wagner, H., and Harris, A. W., J. Immun., 108 : 1353 (1972).
Henney, C. S., Transplant. Rev., 17, 37 (1973).
Canty, T. G., and Wunderlich, J. R., J. natn. Cancer Inst., 45, 761 (1970).
Henney, C. S., and Mayer, M. M., Cell. Immun., 2, 702 (1971).
Rosenau, W., Fed. Proc., 27, 34 (1968).
Henney, C. S., J. Immun., 110, 73 (1973).
Goldberg, B., and Green, H., J. exp. Med., 109, 505 (1959).
Scott, J. G., Weed, R. I., and Swisher, S. N., J. Immun., 96, 119 (1966).
Brunner, K. T., Mauel, J., Cerottini, J-C., and Chapuis, B., Immunology, 14, 181 (1968).
Wilson, D. B., J. exp. Med., 122, 143 (1965).
Cerottini, J-C., and Brunner, K. T., Nature new Biol., 237, 272 (1972).
Plaut, M., Lichtenstein, L. M., and Henney, C. S., J. Immun., 110, 771 (1973).
Henney, C. S., and Bubbers, J. E., J. Immun., 111, 85 (1973).
Yoshinaga, M., Waksman, B. H., and Malawista, S. E., Science, 176, 1147 (1972).
Pappenheimer, J. R., Renkin, E. M., and Borrero, L. M., Am. J. Physiol., 167, 13 (1951).
Grotte, G., Acta. chir. scand. (Suppl.) 211 (1956).
Green, H., Barrow, P., and Goldberg, B., J. exp. Med., 110, 699 (1959).
Martz, E., and Benacerraf, B., J. Immun., 111, 1538 (1973).
Seeman, P., Fed. Proc. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HENNEY, C. Estimation of the size of a T-cell-induced lytic lesion. Nature 249, 456–458 (1974). https://doi.org/10.1038/249456a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249456a0
This article is cited by
-
Melittin-induced membrane permeability: A nonosmotic mechanism of cell death
In Vitro Cellular & Developmental Biology - Animal (2005)
-
Perforin and its role in T lymphocyte-mediated cytolysis
Experientia (1992)
-
Binding of51Cr to human erythrocytes
Biological Trace Element Research (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
