Abstract
Within or close to the major histocompatibility complex (MHC) of man and mouse there are genetic loci which control the production of lymphocyte-associated determinants capable of stimulating allogeneic lymphocytes to synthesise DNA in mixed lymphocyte culture1,2. In the mouse the mixed lymphocyte reaction (MLR) is also controlled by an additional locus, the M locus, which is not linked to MHC3. These MLR loci seem to be distinct from the loci coding for serologically defined (SD) antigens1,2,4. Recent studies suggest that, in certain situations, a genetic difference between responder and stimulator cells is not an absolute requirement in MLR. Thus, Howe et al.5 and Boehmer et al.6,7 found that thymus cells from certain mouse strains produce high levels of thymidine incorporation when cultured with syngeneic B lymphocytes.
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VON BOEHMER, H., SPRENT, J. Expression of M locus differences by B cells but not T cells. Nature 249, 363–365 (1974). https://doi.org/10.1038/249363a0
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DOI: https://doi.org/10.1038/249363a0
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