Abstract
OBSERVATIONS which do not harmonise with the original self-replicative scheme of DNA synthesis have received little attention. In particular, interest in cytoplasmic DNA synthesis in eukaryotic cells has been limited to semiautonomous structures which contain DNA templates. But it was pointed out1 as early as 1958 that transfer of genetic information between DNA, RNA and protein often can proceed in either direction. It is possible that an initial step of DNA synthesis, corresponding for example to RNA-primed synthesis of Okazaki fragments2,3, may generally occur out of cell nuclei and without direct participation of a DNA template.
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BUCHOWICZ, J. Is the cytoplasm a site of nuclear DNA synthesis?. Nature 249, 350 (1974). https://doi.org/10.1038/249350a0
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DOI: https://doi.org/10.1038/249350a0
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