Abstract
X-LINKED recessive (Duchenne) muscular dystrophy (DMD) is the most common, consistent, and disastrous form of the diseases in man. Evidence that it is neurogenic1 is open to criticism2,3. Though an apparently similar condition in mice, often used as a model, may be neurogenic4, its different serology5 and mode of inheritance6 suggest a fundamental dissimilarity. The following observations on the human disease bring new evidence to bear on the issue.
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References
McComas, A. J., Sica, R. E. P., and Currie, S., Nature, 226, 1263–1264 (1970).
Scarpalezos, S., and Panayiotopoulos, C. P., Lancet, ii, 458 (1973).
Desmedt, J. E., and Borenstein, S., Nature, 246, 500–501 (1973).
Hironaka, T., and Miyata, Y., Nature new Biol. 244, 221–223 (1973).
Schapira, F., and Dreyfus, J.-C., Enzymol. biol. clin., 3, 53–57 (1963).
Stevens, L. C., Russell, E. S., and Southard, J. L., Proc. Soc. exp. Biol. Med., 95, 161–164 (1957).
Schwarzacher, H. G., Acta. anat., Basel, 30, 758–774 (1957).
Guth, L., Physiol. Rev., 48, 645–687 (1968).
Le Gros Clark, W. E., The Tissues of the Body (Clarendon Press, Oxford, 1971).
Feinstein, B., Lindegård, B., Nyman, E., and Wohlfart, G., Acta anat., Basel, 23, 127–142 (1955).
Gray's Anatomy (edit. by Warwick, R., and Williams, P. L.) 482 (Longman, Edinburgh, 1973).
Edström, L., and Kugelberg, E., J. Neurol. Neurosurg. Psychiat., 31, 424–433 (1968).
Bonsett, C. A., Neurology, Minneap., 13, 728–738 (1963).
Migeon, B. R., Nature, 239, 87–89 (1972).
Lyon, M. F., Nature, 190, 372–373 (1961).
Moore, K. L., in The Sex Chromatin (edit. by Moore, K. L.) 19 (W. B. Saunders Co., 1966).
Emery, A. E. H., J. med. Genet., 2, 1–7 (1965).
Afifi, A. K., Bergman, R. A., and Zellweger, H., J. Neurol. Neurosurg. Psychiat., 36, 643–650 (1973).
Sweetin, J. C., and Thomson, W. H. S., Clin. chim. Acta, 48, 49–63 (1973).
Wohlfart, G., Neurology, Minneap., 8, 175–180 (1958).
Thomson, W. H. S., Clin. chim. Acta, 26, 207–221 (1969).
Emery, A. E. H., Br. med. J., 2, 418–420 (1969).
Sica, R. E. P., and McComas, A. J., J. Neurol. Neurosurg. Psychiat., 34, 469–474 (1971).
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THOMSON, W., SWEETIN, J. & ELTON, R. The neurogenic and myogenic hypotheses in human (Duchenne) muscular dystrophy. Nature 249, 151–152 (1974). https://doi.org/10.1038/249151a0
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DOI: https://doi.org/10.1038/249151a0
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