Abstract
PLANT virus RNA from the TYMV family1–3, TMV4,5 and BMV6 can be enzymatically esterfied with valine, histidine and tyrosine, respectively. The aminoacylation of intact or fragmented plant virus RNA7, may be an important biological function and, therefore, the question as to whether some mammalian viral RNA can be charged with amino acids becomes significant. In this work, we show that mengovirus RNA can, in fact, be specifically acylated with histidine by a mouse liver aminoacyl-tRNA synthetase preparation.
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References
Pinck, M., Yot, P., Chapeville, F., and Duranton, H. M., Nature, 226, 954 (1970).
Yot, P., Pinck, M., Haenni, A. L., Duranton, H. M., and Chapeville, F., Proc. natn. Acad. Sci. U.S.A., 67, 1345 (1970).
Pinck, M., Chan, S. K., Genevaux, M., Hirth, L., and Duranton, H. M., Biochimie, 54, 1093 (1972).
Öberg, B., and Philipson, L., Biochem. biophys. Res. Commun., 48, 927 (1972).
Litvak, S., Tarragó, A., Tarragó-Litvak, L., and Allende, J. E., Nature new Biol., 241, 88 (1973).
Hall, T. C., Shin, D. S., and Kaesberg, P., Biochem. J., 129, 969 (1972).
Sela, I., Virology, 49, 90 (1972).
Peacock, A. C., and Dingman, C. W., Biochemistry, 7, 668 (1968).
Dahlberg, A. E., Dingman, C. W., and Peacock, A. C., J. molec. Biol., 41, 139 (1969).
Scraba, D. G., Kay, C. M., and Colter, J. S., J. molec. Biol., 26, 67 (1967).
Miller, R. L., and Plagemann, P. G. W., J. gen. Virol., 17, 349 (1972).
Daniel, V., Sarid, S., and Littauer, U. Z., Science, 167, 1682 (1970).
Babinet, C., Biochem. biophys. Res. Commun., 26, 639 (1967).
Muench, K. H., and Berg, P., in Procedures in Nucleic Acid Research (edit. by Cantoni, G. L., and Davies, D. R.), 375 (Harper and Row, New York, 1966).
Littauer, U. Z., Yankofsky, S. A., Novogrodsky, A., Bursztyn, H., Galenter, Y., and Katchalski, E., Biochim. biophys. Acta, 195, 29 (1969).
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SALOMON, R., LITTAUER, U. Enzymatic acylation of histidine to mengovirus RNA. Nature 249, 32–34 (1974). https://doi.org/10.1038/249032a0
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DOI: https://doi.org/10.1038/249032a0
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