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Enzymatic acylation of histidine to mengovirus RNA

Abstract

PLANT virus RNA from the TYMV family1–3, TMV4,5 and BMV6 can be enzymatically esterfied with valine, histidine and tyrosine, respectively. The aminoacylation of intact or fragmented plant virus RNA7, may be an important biological function and, therefore, the question as to whether some mammalian viral RNA can be charged with amino acids becomes significant. In this work, we show that mengovirus RNA can, in fact, be specifically acylated with histidine by a mouse liver aminoacyl-tRNA synthetase preparation.

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SALOMON, R., LITTAUER, U. Enzymatic acylation of histidine to mengovirus RNA. Nature 249, 32–34 (1974). https://doi.org/10.1038/249032a0

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