Abstract
SPECULATION that immunological means could be used to control the sex ratio in mammals began when Eichwald and Silmser1 provided evidence for a Y-linked histocompatibility antigen. Feldman2 and Sachs and Heller3 initially suggested that serum from inbred females immunised by skin from males of the same strain (and assumed to contain antibody specifically directed against the Y antigen) might selectively impair the fertilising ability of sperm containing the Y chromosome. Testing of this hypothesis was hampered by lack of adequate systems for demonstrating and assaying H-Y antibody in the sera of immunised females. Consequently experiments designed to examine the possibility of immunoselection of gametes have until now all been carried out in vivo, and have involved determining the sex ratio of progeny from female mice that had rejected skin grafts from males of the same strain4–6.
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References
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BENNETT, D., BOYSE, E. Sex Ratio in Progeny of Mice Inseminated with Sperm treated with H-Y Antiserum. Nature 246, 308–309 (1973). https://doi.org/10.1038/246308a0
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DOI: https://doi.org/10.1038/246308a0
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