Abstract
DIVINYL ether and maleic anhydride form a 1:2 copolymer, which is reported to have the structure shown here1. It is commonly known as pyran copolymer, although we prefer to call it DIVEMA, an acronym for divinyl ethermaleic anhydride. It has been designated as NSC 46015 by the National Cancer Institute.
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References
Butler, G. B., J. Polym. Sci., 48, 279 (1960).
Espy, H. H., U. S. Patent, 3,224,943 (1965).
Sandberg, J., and Goldin, A., Cancer Chemother. Rep., 55, 233 (1971).
Merigan, T. C., and Regelson, W., N. Engl. J. Med., 277, 1283 (1967).
Regelson, W., Adv. exp. med. Biol., 1, 315 (1967).
Chirigos, M. A., Turner, W., Pearson, J., and Griffin, W., Int. J. Cancer, 4, 267 (1969).
Chirigos, M. A., Comparative Leukaemia Research 1969, Bibl., Haemat., No. 36 (edit. by Dutcher, R. M.), 278 (Karger, Basel, Munchen, Paris, New York, 1970).
DeClercq, E., and Merigan, T. C., J. gen. Virol., 5, 359 (1969).
Merigan, T. C., and Finkelstein, M. S., Virology, 35, 363 (1968).
Schmidt, J. P., Pindak, F. F., Giron, D. J., and Ibarra, R. R., Texas Rep. biol. Med., 29, 133 (1971).
Richmond, J. Y., Infect. Immun., 3, 249 (1971).
Pindak, F. F., Infect. Immun., 1, 271 (1970).
Regelson, W., Munson, A., and Wooles, W., Int. Symp. Standards of Interferon and Interferon Inducers, London, 1969, Symp. Series Immunobiolog. Standards, 14, 227 (Karger, Basel, New York, 1970).
Regelson, W., and Munson, A. E., Ann. N.Y. Acad. Sci., 173, 831 (1970).
Braun, W., Regelson, W., Yajima, Y., and Ishizuko, Proc. Soc. exp. Biol. Med., 133, 181 (1970).
Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., Proc. Soc. exp. Biol. Med., 134, 309 (1970).
Hirsch, M. S., Black, P. H., Wood, M. L., and Monaco, A. P., J. Immun., 108, 1312 (1972).
Kapusta, M. A., and Mendelson, J., Arthr. Rheum., 12, 463 (1969).
Shamash, Y., and Alexander, B., Biochim. biophys. Acta, 194, 449 (1969).
Regelson, W., Miller, G., Breslow, D. S., and Engle, E. J., III, Abstr. Sixth Ann. Meeting Reticuloendothelial Society, paper 13 (1969).
Munson, A. E., Regelson, W., Lawrence, jun., W., and Wooles, W. R., J. reticuloendothel. Soc., 7, 375 (1970).
Butler, G. B., and Wu, C., Abstr. 164th Meeting Ann. Chem. Soc., New York, August, 1972 Section ORPL No. 73.
Coll, H., in Gel Permeation Chromatography (edit. by Altgelt, K. H., and Segal, L.), 137 (Dekker, New York, 1971).
Butler, G. B., J. macromol. Sci. Chem., A 5, 219 (1971).
Shyluck, S., J. Polym. Sci., 62, 317 (1962).
Karrer, K., Humphreys, S. R., and Goldin, A., Int. J. Cancer, 2, 213 (1967).
Hellmann, K., and Burrage, K., Nature, 224, 273 (1969).
Leavitt, T. J., Merigan, T. C., and Freeman, J. M., J. Dis. Child., 121, 43 (1971).
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BRESLOW, D., EDWARDS, E. & NEWBURG, N. Divinyl Ether-Maleic Anhydride (Pyran) Copolymer used to demonstrate the Effect of Molecular Weight on Biological Activity. Nature 246, 160–162 (1973). https://doi.org/10.1038/246160a0
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DOI: https://doi.org/10.1038/246160a0
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