Abstract
VITAMIN D is hydroxylated in the liver to 25-hydroxychole-calciferol (25-HCC)1, and this relatively inactive metabolite is further hydroxylated in the kidney to 1,25-dihydroxychole-calciferol (1,25-DHCC)2 (Fig. 1), the most active form, or to 24,25-dihydroxycholecalciferol (24,25-DHCC)3, a less active metabolite. The proportion formed of these metabolites is markedly influenced by diet4–5, but there is dispute about how this is achieved. One theory h that this involves parathyroid hormone and that this is the essential trophic factor which regulates the production of 1,25-DHCC6. There is strong evidence against this view7, however, and recent studies have cast further doubt: thyroparathyroidectomized rats can increase production of 1,25-DHCC under appropriate dietary stimulus8.
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GALANTE, L., COLSTON, K., EVANS, I. et al. The Regulation of Vitamin D Metabolism. Nature 244, 438–440 (1973). https://doi.org/10.1038/244438a0
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DOI: https://doi.org/10.1038/244438a0
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