Abstract
VERY little information is available concerning the origin of the lymphoid cells of human and animal leukaemias. The lymphoid cell population has been divided into two different functional groups, namely the thymus derived lymphocytes (T cells) mainly involved in cell mediated immunity, and the bone marrow derived lymphocytes (B cells) mediating humoral immunity. These two lymphocyte categories have not been distinguished morphologically, but several specific markers for their identification have been described. The thymus, brain and thymus derived lymphocytes (T cells) bear a cell surface isoantigen θ1 and have very little detectable immunoglobulin molecules on their surface; whereas the bone marrow derived lymphocytes (B cells) have a high density of immunoglobulin determinants on their surface2.
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HARAN-GHERA, N., PELED, A. Thymus and Bone Marrow Derived Lymphatic Leukaemia in Mice. Nature 241, 396–398 (1973). https://doi.org/10.1038/241396a0
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DOI: https://doi.org/10.1038/241396a0
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