This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Roberts J, Prager MD, Bachynsky N . The antitumor activity of Escherichia coli L-asparaginase. Cancer Res 1966; 26: 2213–2217.
Asselin BL, Kurtzberg J . Asparaginase. In: Pui CH (ed). Treatment of Acute Leukemias: New Directions for Clinical Research. Humana Press Inc.: Totowa, NJ, 2003, 365–379.
Ho DH, Whitecar Jr JP, Luce JK, Frei III E . L-Asparagine requirement and the effect of L-asparaginase on the normal and leukemic human bone marrow. Cancer Res 1970; 30: 466–472.
Homans AC, Rybak ME, Baglini RL, Tiarks C, Steiner ME, Forman EN . Effect of L-asparaginase administration on coagulation and platelet function in children with leukemia. J Clin Oncol 1987; 5: 811–817.
Mitchell L, Hoogendoorn H, Giles AR, Vegh P, Andrew M . Increased endogenous thrombin generation in children with acute lymphoblastic leukemia: risk of thrombotic complications in L'asparaginase-induced antithrombin III deficiency. Blood 1994; 83: 386–391.
Steiner M, Attarbaschi A, Kastner U, Dworzak M, Haas OA, Gadner H et al. Distinct fluctuations of ammonia levels during asparaginase therapy for childhood acute leukemia. Pediatr Blood Cancer 2006; 49: 640–642.
Halton JM, Mitchell LG, Vegh P, Eves M, Andrew ME . Fresh frozen plasma has no beneficial effect on the hemostatic system in children receiving L-asparaginase. Am J Hematol 1994; 47: 157–161.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Steiner, M., Attarbaschi, A., Haas, O. et al. Fresh frozen plasma contains free asparagine and may replace the plasma asparagine pool during L-asparaginase therapy. Leukemia 22, 1290 (2008). https://doi.org/10.1038/sj.leu.2405051
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2405051
This article is cited by
-
Advances in Supportive Care for Acute Lymphoblastic Leukemia
Current Hematologic Malignancy Reports (2020)
-
Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan
International Journal of Hematology (2019)