This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Preudhomme C, Fenaux P . The clinical significance of mutations of the p53 tumour suppressor gene in haematological malignancies. Br J Haematol 1997; 98: 502–511.
Bromidge TJ, Howe DJ . Screening of the entire coding region of p53 in low grade lymphoproliferative disorders. J Clin Pathol (Mol Pathol) 2000; 53: 216–218.
Howe DJ, Bromidge TJ, Stack-Dunne M, Davies SV, Paxton A, Phillips MJ et al. Trisomy 12 is a rare event in cases of CLL with typical immunophenotype and morphology. Hematology 1997; 2: 373–378.
Oscier DG, Gardiner AC, Mould SJ, Glide S, Davis ZA, Ibbotson RE et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 2002; 100: 1177–1184.
Bromidge T, Lowe C, Prentice A, Johnson S . p53 intronic point mutation, aberrant splicing and telomeric associations in a case of B-chronic lymphocytic leukaemia. Br J Haematol 2000; 111: 223–229.
Cordone I, Masi S, Romana Mauro F, Soddu S, Morsilli O, Valentini T et al. p53 expression in B-cell chronic lymphocytic leukaemia: a marker of disease progression and poor prognosis. Blood 1998; 91: 4342–4349.
Trbusek M, Malcikova J, Smardova J, Kuhrova V, Mentzlova D, Francova H et al. Inactivation of p53 and deletion of ATM in B-CLL patients in relation in IgVH mutation status and previous treatment. Leukemia 2006; 20: 1159–1161.
Soussi T, Rubio-Nevado JM, Hamroun D, Beroud C . The p53 Mutation Handbook. Available online http://p53.free.fr. Last accessed 25/07/07.
Secchiero P, Barbarotto E, Tiribelli M, Zerbinati C, Grazia di Iasio M, Gonelli A et al. Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL). Blood 2006; 107: 4122–4129.
Acknowledgements
This work was supported by The Musgrove Leukaemic Group Somerset.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bromidge, T., Johnson, S. & Howe, D. Spectrum of p53 mutations in low-grade B-cell malignancies. Leukemia 22, 1071–1073 (2008). https://doi.org/10.1038/sj.leu.2405002
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2405002