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A novel cytogenetic aberration found in stem cell leukemia/lymphoma syndrome

Leukemia volume 22, pages 644–646 (2008)Cite this article

The stem cell leukemia/lymphoma syndrome is characterized by concurrent lymphoma, myeloid proliferation evolving to acute myeloid leukemia (AML) and cytogenetic abnormalities involving 8p11.1, 2 We report a patient who demonstrated similar clinical features accompanied by a novel translocation.

Chemotherapy according to the GMALL protocol resulted in disappearance of clinical symptoms. Nevertheless, repeated bone marrow examination demonstrated persistent myelofibrosis and the same cytogenetic aberration. Methotrexate and cytarabine were administered at high doses. In December 2006, leukocytosis 30 × 109 per litre with 20% blastosis occurred. The circulating blasts showed myelomonocytic morphology, stained for myeloperoxidase and expressed CD33 and CD13 antigens. The bone marrow findings were consistent with the diagnosis of AML with fibrosis (Figure 1b and c). The patient underwent stem cell transplantation from a HLA-matched unrelated donor, but he died with overt leukemia and sepsis shortly afterwards.

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Figure 1

References

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Authors and Affiliations

  1. Hematology Institute, Kaplan Medical Center, Rehovot, Israel

    L Shvidel, E Sigler, E Vorst, M Shtalrid & A Berrebi

  2. Pathology Department, Kaplan Medical Center, Rehovot, Israel

    E Feldberg

  3. Cytogenetics Laboratory, Kaplan Medical Center, Rehovot, Isreal,

    N Voskoboinic

  4. affiliated to the School of Medicine, Hebrew University and Hadassah, Jerusalem, Israel

    N Voskoboinic

Authors
  1. L Shvidel
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  2. E Sigler
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  3. E Vorst
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  4. E Feldberg
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  5. N Voskoboinic
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  6. M Shtalrid
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  7. A Berrebi
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Correspondence to A Berrebi.

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Shvidel, L., Sigler, E., Vorst, E. et al. A novel cytogenetic aberration found in stem cell leukemia/lymphoma syndrome. Leukemia 22, 644–646 (2008). https://doi.org/10.1038/sj.leu.2404942

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