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Different genomic imbalances in low- and high-grade HCV-related lymphomas

Leukemia volume 22, pages 219–222 (2008)Cite this article

Chronic infection with hepatitis C virus (HCV) is related to monoclonal B-cell lymphoproliferative disorders including a benign monoclonal lymphoproliferation such as type II mixed cryoglobulinemia, and B-cell non-Hodgkin's lymphomas (NHL).

Monoclonal B cells in both mixed cryoglobulinemia and HCV-associated NHL frequently express an idiotype encoded by the VH1-69 heavy chain and the kv325 light chain variable genes,1 a putative signature for anti-HCV specificity.

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Acknowledgements

We thank E Pescarmona for providing paraffin samples of lymph node biopsies and helpful discussion. We thank Dr Geraldine A Boyd for assistance in the preparation of the manuscript. This work was supported by grants from AIRC (Associazione Italiana Ricerca sul Cancro); PRIN 2005; EU (European Community); Fondazione Cenci Bolognetti, University of Rome ‘La Smapienza’; AULL (Associazione Umbra Leucemie e Linfomi); Associazione Sergio Luciani, Fabriano; Fondazione Cassa di Risparmio di Perugia. BC is supported by FIRC (Fondazione Italiana per la Ricerca sul Cancro).

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Author notes

  1. C Matteucci and M Bracci: These authors contributed equally to this work

Authors and Affiliations

  1. Division of Hematology, Cytogenetic and Molecular Genetic Unit, IBiT Foundation, University of Perugia, Perugia, Italy

    C Matteucci, G Barba, E Varasano, G Roti, R La Starza, B Crescenzi, M F Martelli & C Mecucci

  2. Division of Clinical Immunology, University ‘La Sapienza’, Rome, Italy

    M Bracci, M Carbonari, M Casato, M Visentini & M Fiorilli

  3. Division of Hematology, University ‘La Sapienza’, Rome, Italy. E-mail: crimecux@unipg.it,

    A Pulsoni

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  1. C Matteucci
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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Matteucci, C., Bracci, M., Barba, G. et al. Different genomic imbalances in low- and high-grade HCV-related lymphomas. Leukemia 22, 219–222 (2008). https://doi.org/10.1038/sj.leu.2404872

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