Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Reply to ‘Myeloproliferative disorders with coexisting BCR-ABL translocation and JAK2V617F mutation’ by Dr Ronald S Go

Leukemia volume 21, page 2052 (2007)Cite this article

The letter from Dr Ronald S Go1 raised interesting questions that will be important to resolve in future studies of chronic myelogenous leukemia (CML).

Dr Go stated that there was a published case of CML with the JAK2V617F mutation earlier to our report;2, 3 however, that was a case of CML having an atypical clinical course, with a late appearance of the Philadelphia chromosome.4, 5, 6 In our report, we described a typical CML case with an onset before the development of erythrocytosis.7

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Go RS . Myeloproliferative disorders with coexisting BCR-ABL translocation and JAK2V617F mutation. Leukemia 2007, in press.

  2. Scott LM, Campbell PJ, Baxter EJ, Todd T, Stephens P, Edkins S et al. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood 2005; 106: 2920–2921.

    Article  CAS  Google Scholar 

  3. Curtin NJ, Campbell PJ, Green AR . The Philadelphia translocation and pre-existing myeloproliferative disorders. Br J Haematol 2005; 128: 734–736.

    Article  CAS  Google Scholar 

  4. Cervantes F, Colomer D, Vives-Corrons JL, Rozman C, Montserrat E . Chronic myeloid leukemia of thrombocythemic onset: a CML subtype with distinct hematological and molecular features? Leukemia 1996; 10: 1241–1243.

    CAS  PubMed  Google Scholar 

  5. Emilia G, Marasca R, Zucchini P, Temperani P, Luppi M, Torelli G et al. BCR-ABL rearrangement is not detectable in essential thrombocythemia. Blood 2001; 97: 2187–2189.

    Article  CAS  Google Scholar 

  6. Michiels JJ, Berneman Z, Schroyens W, Kutti J, Swolin B, Ridell B et al. Philadelphia (Ph) chromosome-positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood: natural history and diagnostic differentiation from Ph-negative essential thrombocythemia. Ann Hematol 2004; 83: 504–512.

    Article  Google Scholar 

  7. Inami M, Inokuchi K, Okabe M, Kosaka F, Mitamura Y, Yamaguchi H et al. Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia. Leukemia 2007; 21: 1103–1104.

    Article  CAS  Google Scholar 

  8. Hussein K, Bock O, Seegers A, Flasshove M, Henneke F, Buesche G et al. Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. Blood 2007; 109: 4106–4107.

    Article  CAS  Google Scholar 

  9. Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 2007; 356: 459–468.

    Article  CAS  Google Scholar 

  10. Kronenwett R, Graf T, Neumann F, Pechtel S, Steidl U, Diaz-Blanco E et al. Absence of the JAK2 mutation V617F in CD34+ hematopoietic stem and progenitor cells from patients with BCR-ABL-positive CML in chronic phase and blast crisis. Leuk Res 2006; 30: 1323–1324.

    Article  CAS  Google Scholar 

  11. Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A et al. A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia. Genes Chromosomes Cancer 2005; 44: 329–333.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan

    M Inami, K Inokuchi, H Yamaguchi & K Dan

Authors
  1. M Inami
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K Inokuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K Dan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Inami.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Inami, M., Inokuchi, K., Yamaguchi, H. et al. Reply to ‘Myeloproliferative disorders with coexisting BCR-ABL translocation and JAK2V617F mutation’ by Dr Ronald S Go. Leukemia 21, 2052 (2007). https://doi.org/10.1038/sj.leu.2404826

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404826

This article is cited by

Search

Advanced search

Quick links