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Association of folate transporter SLC19A1 polymorphisms with the outcome of multiple myeloma after chemotherapy and tandem autologous transplantation

Leukemia volume 21, pages 176–178 (2007)Cite this article

Patients with multiple myeloma (MM) have a median survival of 3 years when treated with standard-dose chemotherapy. An improved survival of approximately 18 months has been shown with high-dose therapy coupled with stem cell rescue (autologous stem cells transplantation, ASCT). However, despite initial good responses, most patients relapse.1

Traditional prognostic factors account for only 15–20% of outcome heterogeneity in MM patients.1 New prognostic factors can also be considered relevant for the therapeutic response, such as single nucleotide polymorphisms (SNPs) in genes involved in the transport of antitumor drugs, and their impact could be established by a pharmacogenetic approach.

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Acknowledgements

We thank Pier Paolo Fattori, MD, Anna Maria Mianulli, MD, and Manuela Imola, MD, for their contribution to patient recruitment. We acknowledge the support of Mrs Alison Frank in revising the English language.

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Author notes

  1. V Maggini and G Buda: These two authors contributed equally to this study.

Authors and Affiliations

  1. Department of Biology, Pisa University, Pisa, Italy

    V Maggini, E Conidi, R Barale & A M Rossi

  2. Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy

    G Buda, S Galimberti & M Petrini

  3. Department of Internal Medicine and Biomedical Science, Hematology and BMT Center, Parma University, Parma, Italy

    N Giuliani & V Rizzoli

  4. Haematology Service – S Annunziata Hospital, Cosenza, Italy

    F Morabito

  5. Department of Oncology, Division of Onco-Hematology, Infermi Hospital, Rimini, Italy

    G Genestreti

  6. Hematology Department, Bone Marrow Transplant Unit, AO Reggio Calabria, Italy

    P Iacopino

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  1. V Maggini
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  2. G Buda
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  9. V Rizzoli
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  10. R Barale
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Correspondence to V Maggini.

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Maggini, V., Buda, G., Galimberti, S. et al. Association of folate transporter SLC19A1 polymorphisms with the outcome of multiple myeloma after chemotherapy and tandem autologous transplantation. Leukemia 21, 176–178 (2007). https://doi.org/10.1038/sj.leu.2404455

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