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Prospective multicentric molecular study for poor prognosis fusion transcripts at diagnosis in adult B-lineage ALL patients: the LALA 94 experience

Leukemia volume 20, pages 2178–2181 (2006)Cite this article

Given the therapeutic progress achieved over the last few decades, any improvement in the outcome for the majority of patients with acute lymphoblastic leukemia (ALL) is difficult to assess with the size of the trials. Furthermore, the progress in genetics and molecular biology have now led to the identification of subgroups of patients, typically with poor prognosis markers, for whom intensive treatments were rapidly necessary. For both these clinical aspects, there is an increasing need for intergroup cooperation. We suggest here that multicentric molecular studies could be made more feasible, with scientific rigor, by adopting a common methodological strategy to provide results readily available for therapeutic stratification.

From 1994 to 2000, 984 adults (sex ratio M/F=1.77) patients aged from 15 to 55 years (median age: 33 years) with newly diagnosed ALL (except patients with a previous history of malignant disease) were enrolled in the LALA-94 trial in 50 clinical centers from four countries (France, Belgium, Switzerland and Australia). The study was approved by the Ethics Committee and all patients gave signed informed consent. Molecular biology data from Australian patients were performed separately and not included in this study. In this trial, patient stratification for the second randomization after induction therapy is based on poor prognosis factors defined in adult ALL based on the French ALL protocol.1, 2 The t(9;22), t(1;19) and t(4;11) translocations and/or their molecular equivalents were considered as independent poor prognosis factors. To do so a group of six laboratories, then extended to 16, combined to identify the four corresponding fusion transcripts (BCR-ABL (m- and M-BCR), E2A-PBX1 and MLL-AF4, respectively) in order to provide data before the second randomization (J35).

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Acknowledgements

This work has been in part supported by the national ARC Grants no 9654 and no 5484. The following hospitals participated in the LALA-94 trial: Groupe d'Etude et de Traitement de la Leucémie Aiguë Lymphoblastique de l'Adulte (GET-LALA Group) – Hôpital Edouard Herriot, Lyon; Hôpital Saint-Louis, Paris; Hôpital du Haut Levêque, Pessac; Hôpital Purpan, Toulouse; Hôpital Henri Mondor, Créteil; Hôpital Pitié-Salpétrière, Paris; Institut Paoli Calmettes, Marseille; Hôpital Cochin, Paris; Hôpital de Hautepierre, Strasbourg; Hôpital de l'Archet, Nice; Hôpital Necker, Paris; Hôpital Jean Bernard, Poitiers; Hôpital Michallon, Grenoble; Institut Gustave Roussy, Villejuif; Hôpital du Bocage, Dijon; Hôpital Saint-Antoine, Paris; Centre Hospitalier, Caen; Hôpital Pontchaillou, Rennes; Centre Hospitalier de la Côte Basque, Bayonne; Centre Hospitalier Lyon-Sud, Pierre Bénite; HIA Percy, Clamart; Centre Hospitalier, Chambéry; Hôpital Dupuytren, Limoges; Centre Hospitalier, Avignon; Hôpital Louis Pasteur, Colmar; Centre Henri Becquerel, Rouen; Centre Hospitalier, Lille; Hôtel Dieu, Clermont-Ferrand; Hôpital André Mignot, Versailles; Hôpital Beaujon, Clichy; Centre Hospitalier, Annecy; Centre Hospitalier Lapeyronie, Montpellier; Centre Hospitalier, Aix en Provence; Hôpital Jean Monod, Le Havre; Hôpital Lariboisière, Paris; Hôpital Victor Dupouy, Argenteuil; Centre Hospitalier Dr Schaffner, Lens; Centre Antoine Lacassagne, Nice; Centre Hospitalier, Meaux; Centre Hospitalier, Perpignan; Clinique St Vincent, Lille; Centre Hospitalier, Nîmes; Centre Hospitalier, Roubaix, France. Cliniques St Luc, Bruxelles; Centre Hospitalier Notre Dame et Reine Fabiola, Charleroi; Cliniques de Mont Godinne, Yvoir; ASBL, Loverval; Hôpital Saint Joseph, Gilly; Hôpital de Jolimont, Haine St Paul; Hôpital St Joseph, Mons; Hôpital de la Citadelle, Liège; Laboratoire de Cytogénétique, Leuven, Belgium. Swiss Group for Clinical Cancer Research (SAKK) – Centre Hospitalier Universitaire Vaudois, Lausanne; Kantonsspital, St Gallen; Universitätsspital, Zürich; Hôpital Cantonal Universitaire, Genève; Kantonsspital, Basel; Inselspital, Bern; Kantonsspital, Winterthur; Kantonsspital, Luzern, Switzerland.

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Author notes

  1. J Gabert

    Present address: Department of Biochemistry and Molecular Biology, IFR Jean Roche, Faculté de Médecine NORD, Bd Pierre Dramard, 13916, Marseille, Cedex 20, France

Authors and Affiliations

  1. Laboratoire de Biochimie et Biologie Moléculaire, Chemin des Bourrelys APHM-Hôpital Nord, & ERT MEIDIA, Marseille, France

    C Picard & J Gabert

  2. Laboratoire d'Hématologie, Hôpital Edouard Herriot, Lyon, France

    S Hayette, V Lhéritier, X Thomas, C Charrin & D Fière

  3. Département d'Hématologie, Hôpital du Haut Lévêque, Pessac, France

    C Bilhou-Nabera

  4. Laboratoire d'Hématologie, Hôpital Saint-Louis, Paris, France

    J M Cayuela & H Dombret

  5. Laboratoire d'Hématologie, Hôpital Necker, Paris, France

    E Delabesse & E MacIntyre

  6. Laboratoire de Biochimie et Biologie Moléculaire, Hôpital Paul Brousse, Villejuif, France

    N Frenoy

  7. Laboratoire d'Hématologie, Hôpital Claude Huriez, Lille, France

    C Preudhomme

  8. Laboratoire de Biochimie et Biologie Moléculaire, Hôpital A. de Villeneuve, Montpellier, France

    M Dupont

  9. Laboratoire de Génétique oncologique, Centre Henri Becquerel, Rouen, France

    C Bastard

  10. Laboratoire d'Hématologie, Centre Hospitalier Henri Mondor, Créteil, France

    D Bories

  11. UCL, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique

    J L Vaerman

  12. Laboratoire d'Hématologie, Hôpital Pitié Salpétrière, Paris, France

    F Davi

  13. Laboratoire d'hématologie, Hôpital Purpan, Toulouse, France

    N Dastugue

  14. Laboratoire de Cytogénétique, Centre Hospitalier Universitaire, Nice, France

    S Raynaud

  15. Laboratoire d'Hématologie, Institut Paoli Calmettes et UMR599, Marseille, France

    M Lafage & J Gabert

  16. Laboratoire d'Hématologie, Centre Hospitalier, Besançon, France

    F Deschaseaux & T Fest

  17. Laboratoire de Biochimie et Biologie Moléculaire, Hôpital de Hautepierre, Strasbourg, France

    M P Gaub

  18. Unité INSERM U268, Villejuif, France

    C Boucheix

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Corresponding author

Correspondence to J Gabert.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Picard, C., Hayette, S., Bilhou-Nabera, C. et al. Prospective multicentric molecular study for poor prognosis fusion transcripts at diagnosis in adult B-lineage ALL patients: the LALA 94 experience. Leukemia 20, 2178–2181 (2006). https://doi.org/10.1038/sj.leu.2404408

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