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Novel Ig V gene features of t(14;18) and t(3;14) de novo diffuse large B-cell lymphoma displaying germinal center-B cell like and non-germinal center-B cell like markers

Leukemia volume 20, pages 2070–2074 (2006)Cite this article

Reciprocal chromosomal translocations are a hallmark of many B-cell lymphomas, and are frequently seen as recurrent abnormalities. As such, they appear to delineate specific subsets in individual lymphoma categories. Their occurrence also raises the question whether they might associate with distinct pathways of clonal origins or tumor behavior. The reciprocal translocations that juxtapose immunoglobulin (Ig) gene loci and proto-oncogenes are of particular interest, as they result in upregulated proto-oncogene expression, owing to translocated Ig enhancer elements. These types of translocations are important in diffuse large B-cell lymphoma (DLBCL), a disease that displays marked heterogeneity in presentation and outcome. Of note, the t(14;18)(q32;q21) and t(3;14)(q27;q32) translocations are two of the most frequent translocations observed in DLBCL. They dysregulate expression of the antiapoptotic protein BCL2, or the germinal center (GC) transcription factor BCL6, respectively, and it is thought that aberrant expression of these molecules may initiate distinctive pathogenetic mechanisms.1

In order to track how defined chromosomal abnormalities may associate with specific tumor origins in DLBCL, investigators have recently begun to exploit insights emerging from gene expression profiles.2 These profiles provide a means of classifying disease heterogeneity in DLBCL, and have defined three distinct tumor subtypes that have a prognostic and biological relevance.2 The germinal center-B cell like (GCB) subset is characterized by an expression profile resembling that of normal GC B-cells. The activated-B-cell-like (ABC) profile is characterized by expression of genes normally induced during in vitro activation of B-cells, and Type 3 profiles represent expression of heterogeneous GCB or ABC genes.2 In order to simplify the methodological requirement for identification of GC/non-GCB signatures in DLBCL, Hans et al. have established a cohort of genes that can be evaluated by immunohistochemistry (IHC).3 They have shown that the IHC criteria can achieve a GC/non-GCB designation that is able to predict survival as well as complementary DNA microarray profiles.

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Acknowledgements

This work was supported by grants from the Comité de L’Eure de la Ligue contre le Cancer. Grant support for SSS is from the Leukaemia Research Fund (UK) and the Research Fund for Waldenstrom's Ltd. (USA).

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Authors and Affiliations

  1. Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France

    F Jardin, S Lepretre & H Tilly

  2. Laboratory of genetic oncology and lymphoproliferation study group, INSERM U614, IFR 23, Rouen, France

    F Jardin, P Ruminy, F Parmentier, V Rainville, G Buchonnet, H Tilly & C Bastard

  3. Cancer Sciences Division, Genetic Vaccine Group, School of Medicine, University of Southampton, Southampton, UK

    S S Sahota

  4. Department of Pathology, Centre Henri Becquerel, Rouen, France

    J M Picquenot

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Correspondence to F Jardin.

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Jardin, F., Sahota, S., Ruminy, P. et al. Novel Ig V gene features of t(14;18) and t(3;14) de novo diffuse large B-cell lymphoma displaying germinal center-B cell like and non-germinal center-B cell like markers. Leukemia 20, 2070–2074 (2006). https://doi.org/10.1038/sj.leu.2404370

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