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C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12

Leukemia volume 19, pages 1682–1683 (2005)Cite this article

TO THE EDITOR

Recent studies provided evidence for a novel function of complement C3a in the biology of hematopoietic progenitor cells (HPCs). C3a enhanced the responsiveness of HPCs to CXCL12 chemokine in a chemotactic assay.1 In vivo, C3a enhanced HPC homing to bone marrow and accelerated their engraftment after transplantation.1 Complement fragments also promoted HPC retention in bone marrow.2

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References

  1. Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem / progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 2003; 101: 3784–3793.

    Article  CAS  Google Scholar 

  2. Ratajczak J, Reca R, Kucia M, Majka M, Allendorf DJ, Baran JT et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem / progenitor cells in bone marrow. Blood 2004; 103: 2071–2078.

    Article  CAS  Google Scholar 

  3. Ratajczak MZ, Reca R, Wysoczynski M, Kucia M, Baran JT, Allendorf DJ et al. Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells. Leukemia 2004; 18: 1482–1490.

    Article  CAS  Google Scholar 

  4. Cain SA, Monk PN . The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg. J Biol Chem 2002; 277: 7165–7169.

    Article  CAS  Google Scholar 

  5. Kalant D, Cain SA, Maslowska M, Sniderman AD, Cianflone K, Monk PN . The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77 / acylation-stimulating protein. J Biol Chem 2003; 278: 11123–11129.

    Article  CAS  Google Scholar 

  6. Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB et al. C5L2, a nonsignaling C5A binding protein. Biochemistry 2003; 42: 9406–9415.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the following grants from the National Institute of Health: AI 42987 (to AN-W), HL36162 (to NPG), HL56949 (to LES), HL69511 (to CG).

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Authors and Affiliations

  1. Joint Program in Transfusion Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA

    M Honczarenko & L E Silberstein

  2. Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA

    B Lu, N P Gerard & C Gerard

  3. Divisions of Allergy-Inflammation and Infectious Diseases at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    A Nicholson-Weller

Authors
  1. M Honczarenko
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  2. B Lu
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  3. A Nicholson-Weller
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  4. N P Gerard
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  5. L E Silberstein
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  6. C Gerard
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Correspondence to M Honczarenko.

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Honczarenko, M., Lu, B., Nicholson-Weller, A. et al. C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia 19, 1682–1683 (2005). https://doi.org/10.1038/sj.leu.2403862

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  • DOI: https://doi.org/10.1038/sj.leu.2403862

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