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Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarrays

Leukemia volume 19, pages 1082–1084 (2005)Cite this article

TO THE EDITOR

Within the spectrum of diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBL) is a distinct entity, based not only on its biological characteristics but also on its unique pattern of genetic features.1 PMBL appears to be more similar to classical Hodgkin's lymphoma (cHL) than DLBCL; both exhibit common genetic changes including amplification of chromosome 2p13 and 9p24 as well as similar gene expression profiles.2, 3, 4 In chromosome 9p24, JAK2 has been considered as a candidate oncogene, based on recent studies revealing high JAK2 transcription2, 4 and constitutive phosphorylation in PMBL.5

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References

  1. Barth TF, Leithauser F, Joos S, Bentz M, Moller P . Mediastinal (thymic) large B-cell lymphoma: where do we stand? Lancet Oncol 2002; 3: 229–234.

    Article  Google Scholar 

  2. Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003; 102: 3871–3879.

    Article  CAS  Google Scholar 

  3. Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003; 198: 851–862.

    Article  CAS  Google Scholar 

  4. Joos S, Otano-Joos MI, Ziegler S, Bruderlein S, du Manoir S, Bentz M et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood 1996; 87: 1571–1578.

    CAS  Google Scholar 

  5. Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland ML, Le Gouvello S, Gaulard P et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood 2004; 104: 543–549.

    Article  CAS  Google Scholar 

  6. Melzner I, Bucur AJ, Bruderlein S, Dorsch K, Hasel C, Barth TF et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line. Blood 2004; Nov 30 [E-pub ahead of print] PMID: 15572583 [PubMed – as supplied by publisher].

  7. Rubio-Moscardo F, Climent J, Siebert R, Piris MA, Martin-Subero JI, Nielander I et al. Mantle cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome. Blood 2005; Feb 17 [E-pub ahead of print]. PMID: 15718413 [PubMed – as supplied by publisher].

  8. Alizadeh A, Eisen M, Davis RE, Ma C, Sabet H, Tran T et al. The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harb Symp Quant Biol 1999; 64: 71–78.

    Article  CAS  Google Scholar 

  9. Nacheva E, Dyer MJ, Metivier C, Jadayel D, Stranks G, Morilla R et al. B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression. Blood 1994; 84: 3422–3428.

    CAS  PubMed  Google Scholar 

  10. Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001; 28: 29–35.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

    C Mestre, F Rubio-Moscardo, J Climent & J A Martinez-Climent

  2. Department of Hematology and Medical Oncology, Hospital Clínico, University of Valencia, Spain

    C Mestre, F Rubio-Moscardo, J Climent & J A Martinez-Climent

  3. Department of Pathology, University of Würzburg, Germany

    A Rosenwald

  4. MRC Toxicology Unit, University of Leicester, UK

    M J S Dyer

  5. Center for Cancer Research, National Cancer Institute, Bethesda, USA

    L Staudt

  6. Cancer Research Institute, University of California, San Francisco, CA, USA

    D Pinkel

  7. Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel, Germany

    R Siebert

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  1. C Mestre
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  2. F Rubio-Moscardo
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  8. R Siebert
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  9. J A Martinez-Climent
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Correspondence to J A Martinez-Climent.

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Mestre, C., Rubio-Moscardo, F., Rosenwald, A. et al. Homozygous deletion of SOCS1 in primary mediastinal B-cell lymphoma detected by CGH to BAC microarrays. Leukemia 19, 1082–1084 (2005). https://doi.org/10.1038/sj.leu.2403741

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