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Outcome of myeloablative allogeneic stem cell transplantation in multiple myeloma with a 153Sm-EDTMP-based preparative regimen

Leukemia volume 19, pages 879–880 (2005)Cite this article

TO THE EDITOR

We read with interest the recent article by Dispenzieri et al1 relating to use of the radiolabeled bone-seeking agent 153Sm-ethylenediaminetetramethyene phosphate (153Sm-EDTMP; Quadramet®) in autologous stem cell transplantation (SCT) for multiple myeloma (MM). Their findings suggest that addition of 153Sm-EDTMP to a melphalan-based preparative regimen is well tolerated, with no increased toxicity experienced above that expected with use of melphalan alone. This potentially allows a means of augmenting antimyeloma chemotherapy without increasing toxicity.

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References

  1. Dispenzieri A, Wiseman GA, Lacy MQ, Litzow MR, Anderson PM, Gastineau DA et al. A phase I study of 153Sm-EDTMP with fixed high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma. Leukemia 2005; 19: 118–125.

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Authors and Affiliations

  1. Division of Oncology, Royal Brisbane and Women's Hospital, Queensland, Australia

    G A Kennedy, S Durrant, J Butler, J Morton, R Western & R Allison

  2. Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Queensland, Australia

    M L Bartlett & D J MacFarlane

Authors
  1. G A Kennedy
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  2. S Durrant
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  3. J Butler
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  4. J Morton
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  5. R Western
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  6. M L Bartlett
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  7. R Allison
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  8. D J MacFarlane
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Correspondence to G A Kennedy.

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Kennedy, G., Durrant, S., Butler, J. et al. Outcome of myeloablative allogeneic stem cell transplantation in multiple myeloma with a 153Sm-EDTMP-based preparative regimen. Leukemia 19, 879–880 (2005). https://doi.org/10.1038/sj.leu.2403698

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  • DOI: https://doi.org/10.1038/sj.leu.2403698

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