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Philadelphia (Ph1)-negative myeloid/natural killer cell precursor leukemia evolving during Ph1-positive chronic myelogenous leukemia: report of two cases

Leukemia volume 18, pages 2036–2038 (2004)Cite this article

TO THE EDITOR

Chronic myelogenous leukemia (CML) is the clonal expansion of hematopoietic progenitor cells. The chronic phase of expanded clonal myelopoiesis lasts several years, but commonly evolves slowly into the accelerated phase and then finally to a blast crisis, which is usually derived from a Philadelphia chromosome (Ph1)-positive clone. Natural killer (NK) cells decrease in number and in function during CML progression from chronic phase of blastic crisis1 and become Bcr/Abl+ late in the disease course.2 Furthermore, very rare cases of blast crisis associated with CML showing features similar to those described in acute myeloid/NK cell precursor leukemia have been described. Here, we report two sequential CML cases that developed Ph1-negative myeloid/NK cell precursor leukemia during the chronic phase.

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Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Nephrology and Rheumatology, Kinki University School of Medicine, Osaka, Japan

    M Matsuda, Y Morita, T Sano, M Tanaka, Y Tatsumi, Y Maeda & A Kanamaru

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  1. M Matsuda
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  2. Y Morita
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Correspondence to M Matsuda.

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Matsuda, M., Morita, Y., Sano, T. et al. Philadelphia (Ph1)-negative myeloid/natural killer cell precursor leukemia evolving during Ph1-positive chronic myelogenous leukemia: report of two cases. Leukemia 18, 2036–2038 (2004). https://doi.org/10.1038/sj.leu.2403546

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