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Susceptibility of malignant plasma cells to HA-1H specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect

Leukemia volume 18, pages 1543–1545 (2004)Cite this article

TO THE EDITOR

Allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusions (DLIs) can induce durable remissions in patients with multiple myeloma (MM). This beneficial graft-versus-myeloma (GvM) effect is largely mediated by immunocompetent, allo-reactive donor T cells present in the stem cell grafts, as suggested by the close correlation between the occurrence of graft-versus-host disease (GvHD) and clinical response to DLI.1, 2

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Acknowledgements

This work was supported by the Multiple Myeloma Research Foundation, the Visser Foundation and the University Medical Center Utrecht.

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Authors and Affiliations

  1. Department of Hematology, University Medical Center Utrecht, The Netherlands

    P A Holloway, M van Dijk, T Mutis & H M Lokhorst

  2. Department of Immunology, University Medical Center Utrecht, The Netherlands

    N Kaldenhoven & A C Bloem

  3. Hubrecht Laboratory Utrecht, The Netherlands

    W de Lau

  4. Department of Infectious Disease and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

    R van der Zee

  5. Division of Hematology and Oncology, Department of Internal Medicine, Laboratory for Tumor and Immunobiology, Innsbruck University Hospital, Innsbruck, Austria

    B Kircher-Eibl

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  1. P A Holloway
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Correspondence to H M Lokhorst.

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Holloway, P., Kaldenhoven, N., van Dijk, M. et al. Susceptibility of malignant plasma cells to HA-1H specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect. Leukemia 18, 1543–1545 (2004). https://doi.org/10.1038/sj.leu.2403445

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