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Expression of APO2.7, bcl-2 and bax apoptosis-associated proteins in CD34− bone marrow cell compartments from patients with myelodysplastic syndromes

Leukemia volume 18, pages 1311–1313 (2004)Cite this article

TO THE EDITOR

Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell disorders in which excessive apoptosis has been involved. It has been postulated that this phenomenon in MDS patients could help to explain the ineffectiveness of haematopoiesis and may contribute to the development of peripheral cytopenias, more frequently observed in early MDS. This increased intramedullary apoptosis has been demonstrated through different methodological approaches. However, discrepant results have been reported and, therefore, their clinical interpretation remains controversial. Among other factors, the cellular heterogeneity of bone marrow (BM) samples in MDS together with the use of different ex vivo methods to identify apoptotic cells may explain, at least in part, such discrepancies. On the other hand, precise information on the cell type undergoing apoptosis is frequently lacking since results usually refer to the whole sample cellularity. Finally, most recent studies have focused on BM CD34+ cells, while few reports analyse the more mature BM CD34− cells.1

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Acknowledgements

L Suárez was a recipient of a grant (Ref. 63022) from the ‘Agencia Española de Cooperación Internacional’ from Madrid (Spain) during the first months of the study and from the ‘Secretaría de Estado de Educación y Universidades’ (Ref. SB 2000-0089) as part of the Spanish program ‘Estancia de Profesores, Investigadores, Doctores y Tecnólogos Extranjeros en España.’

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Authors and Affiliations

  1. Department of Hematology, University Hospital, Salamanca, Spain

    L Suárez, M B Vidriales, M C López-Berges & J F San Miguel

  2. Centro de Investigación del Cáncer, Salamanca, Spain

    L Suárez, M B Vidriales, J F San Miguel & A Orfao

  3. Department of Hematology, Hospital La Fe, Valencia, Spain

    G Sanz

  4. Department of Cytometry, University of Salamanca, Spain

    A López, M de Santiago & A Orfao

  5. Department of Hematology, Lozano Blesa Hospital, Zaragoza, Spain

    L Palomera

  6. Department of Hematology, Central de Asturias Hospital, Oviedo, Spain

    T Bernal

  7. Department of Hematology, Navarra Hospital, Pamplona, Spain

    M E Pérez de Equiza

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  1. L Suárez
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  2. M B Vidriales
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  10. J F San Miguel
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Correspondence to M B Vidriales.

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Suárez, L., Vidriales, M., Sanz, G. et al. Expression of APO2.7, bcl-2 and bax apoptosis-associated proteins in CD34− bone marrow cell compartments from patients with myelodysplastic syndromes. Leukemia 18, 1311–1313 (2004). https://doi.org/10.1038/sj.leu.2403386

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