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CD34+ progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma

Leukemia volume 18, pages 1038–1040 (2004)Cite this article

TO THE EDITOR

Myelodysplastic syndrome (MDS) is considered a stem cell disorder, characterized by peripheral blood cytopenia and bone marrow hyperplasia.1 Though the ineffective hematopoiesis may be due to excessive apoptosis in MDS,2 the precise mechanism is unknown. Chemokines are small cytokines that are important as intermediates in the inflammatory response, and are regulatory proteins for the recruitment and trafficking of leukocytes.3 Recently, stromal cell-derived factor-1 (SDF-1) was identified as the predominant chemotactic factor produced by bone marrow cells.4 The SDF-1 and its receptor CXCR4 are involved in the mobilizing and trafficking of hematopoietic progenitor cells.5 SDF-1 also enhances survival/antiapoptosis of hematopoietic progenitor cells, in vitro as well as in vivo,6 suggesting that the SDF-1/CXCR4 system plays an important role in hematopoietic cell regulation. Therefore, we investigated the correlation between apoptosis and the SDF-1/CXCR4 system in CD34+ progenitor cells from patients with MDS.

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Acknowledgements

We would like to thank Drs Osamu Yoshie and Takashi Nakayama of the Department of Bacteriology at the Kinki University School of Medicine for their helpful input.

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Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Nephrology and Rheumatology, Kinki University School of Medicine, Osaka, Japan

    M Matsuda, Y Morita, H Hanamoto, Y Tatsumi, Y Maeda & A Kanamaru

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  1. M Matsuda
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  2. Y Morita
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  3. H Hanamoto
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  4. Y Tatsumi
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  5. Y Maeda
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  6. A Kanamaru
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Correspondence to M Matsuda.

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Matsuda, M., Morita, Y., Hanamoto, H. et al. CD34+ progenitors from MDS patients are unresponsive to SDF-1, despite high levels of SDF-1 in bone marrow plasma. Leukemia 18, 1038–1040 (2004). https://doi.org/10.1038/sj.leu.2403301

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