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The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3–4, is downregulated by hypermethylation in acute lymphoblastic leukemia

Leukemia volume 18, pages 362–365 (2004)Cite this article

TO THE EDITOR

Several reports have shown that abnormal methylation of CpG islands within gene promoters leads to transcriptional silencing and may contribute significantly to the pathogenesis of human leukemias. Hypermethylation of promoters associated with genes involved in the control of the principal late-G1 cell-cycle checkpoint, the apoptotic program and the cell–-cell adhesion is detected with increased frequency in acute lymphoblastic leukemia (ALL).1 This mechanism provides an alternative route to gene mutation of cancer-related genes.

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References

  1. Roman-Gomez J, Castillejo JA, Jimenez A, Gonzalez MG, Moreno F, Rodriguez MC et al. 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21CIP1/WAF1/SDI1gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 2002; 99: 2291–2296.

    Article  CAS  Google Scholar 

  2. Goyal J, Smith KM, Cowan JM, Wazer DE, Lee W, Band V . The role of NES1 serine protease as a novel tumor suppressor. Cancer Res 1998; 58: 4782–4786.

    CAS  PubMed  Google Scholar 

  3. Li B, Goyal J, Dhar S, Goberdhan D, Evron E, Sukumar S et al. CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression. Cancer Res 2001; 61: 8014–8021.

    CAS  PubMed  Google Scholar 

  4. Takeuchi S, Bartram CR, Wada M, Reiter A, Hatta Y, Seriu T et al. Allelotype analysis of childhood acute lymphoblastic leukemia. Cancer Res 1995; 55: 5377–5382.

    CAS  PubMed  Google Scholar 

  5. Malone CS, Miner MD, Doerr JR, Jackson JP, Jacobsen SE, Wall R et al. CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing. Proc Natl Acad Sci USA 2001; 98: 10404–10409.

    Article  CAS  Google Scholar 

  6. Nguyen C, Liang G, Nguyen TT, Tsao-Wei D, Groshen S, Lubbert M et al. Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J Natl Cancer Inst 2001; 93: 1465–1472.

    Article  CAS  Google Scholar 

  7. Dhar S, Bhargava R, Yunes M, Li B, Goyal J, Naber SP et al. Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer. Clin Cancer Res 2001; 7: 3393–3398.

    CAS  PubMed  Google Scholar 

  8. Yousef GM, Diamandis EP . Expanded human tissue kallikrein family – a novel panel of cancer biomarkers. Tumor Biol 2002; 23: 185–192.

    Article  CAS  Google Scholar 

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Acknowledgements

This work is supported by grants from Fondo de Investigaciones Sanitarias (FIS, Spain) 01/0662, 01/0013-01, 01/F018, 02/1299; Navarra Goverment (31/2002); RETIC C03/10 and funds from Cajamar-Fundacion Hospital Carlos Haya (Malaga, Spain).

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Authors and Affiliations

  1. Hematology Department, Molecular Biology Unit, Reina Sofia Hospital, Cordoba, Spain

    J Roman-Gomez, J A Castillejo & A Torres

  2. Hematology Department, Molecular Biology Unit, Carlos Haya Hospital, Malaga, Spain

    A Jimenez-Velasco, M Barrios & A Heiniger

  3. Hematology Department, Cellular Therapy Area, Clinica Universitaria, Pamplona, Spain

    X Agirre, E J Andreu & F Prosper

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  1. J Roman-Gomez
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Correspondence to J Roman-Gomez.

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Roman-Gomez, J., Jimenez-Velasco, A., Agirre, X. et al. The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3–4, is downregulated by hypermethylation in acute lymphoblastic leukemia. Leukemia 18, 362–365 (2004). https://doi.org/10.1038/sj.leu.2403223

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  • DOI: https://doi.org/10.1038/sj.leu.2403223

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